Owen Wilson is one of today's most sought-after comic actors. He frequently appears in films with his brother Luke, Ben Stiller, Will Ferrell and Vince Vaughn. Wilson starred in "The Wedding Crashers," "You, Me and Dupree," and "Meet the Parents." But on Aug. 26, 2007, he reportedly tried to take his own life. The reason is not yet known.
Comedian Richard Jeni died after he shot himself in the head in March 2007. His girlfriend discovered him. Jeni was a frequent guest on late night talk shows and appeared in the comedy documentary "The Aristocrats." In 2005, he hosted the HBO special, "Richard Jeni: A Big Steaming Pile of Me." In 2004, Comedy Central named him No. 57 on its list of the 100 greatest stand-ups of all time.
Comedian Richard Pryor died of multiple sclerosis in 2005. Pryor is famous for setting himself on fire while freebasing cocaine in 1980. He suffered burns to more than 50 percent of his body, but later made a joke about it while doing standup in 1982. Later he told Barbara Walters that he had actually tried to commit suicide, but at the behest of his lawyers he made up the story that it was an accident.
Controversial comedian Rosie O'Donnell openly talked about her struggles with depression while she hosted "The View" in 2007. She demonstrated how she hung upside down as a way of treating her depression. She first discussed it in 2000 in her now-defunct magazine, "Rosie."
John Belushi starred in "Saturday Night Live," "National Lampoon's Animal House" and "The Blues Brothers," but in his personal life he struggled with drug addiction. Belushi died in 1982 at age 33 from a speedball injection of cocaine and heroin.
Robin Williams came to fame while starring on the sitcom "Mork & Mindy" in the late 1970s. He excelled at standup and the movies and won an Oscar for his performance in "Good Will Hunting." In the 1970s and '80s he became seriously addicted to cocaine. His good friend John Belushi's death served as a wakeup call, but in 2006, he entered rehab for alcoholism.
Dave Chappelle starred in the marijuana comedy "Half Baked," and later went on to host his own immensely popular comedy sketch show, "Chappelle's Show." But in 2005, he abandoned his $50 million contract because he said was unhappy with the show; he left the United States for South Africa. Chappelle denied having any drug or mental problems, but questions about his sanity persisted. He now lives in his native Ohio.
Comedian Paula Poundstone -- mother of three adopted children -- was arrested in 2001 for committing lewd acts on a girl under age 14 and for endangering four other minors. She posted bail and pled not guilty. She later went to rehab for alcoholism. Poundstone, who the American Comedy Award for Best Female Comedy Club Stand-Up Comic in 1989, accepted a plea agreement and the three charges of lewd conduct were dropped.
Like John Belushi, Chris Farley got his start at Chicago's Second City Theatre and later went on to star in "Saturday Night Live." He made funny movies like "Tommy Boy" and "Beverly Hills Ninja," but also struggled with drugs. Also suffering from obesity, Farley died at age 33 from a speedball injection.
Standup comedian and writer Lenny Bruce died in 1966 at age 40 from a drug overdose. He was known for his irreverent and controversial routines and was even banned from performing in Sydney, Australia, for using the "f-word." He was arrested for obscenity in California and New York.
Stand-up comedian Freddie Prinze, father of heart-throb Freddie Prinze Jr., starred in the 1970s TV series "Chico and the Man." But he struggled with addictions to quaaludes and cocaine. After his marriage unraveled, he started mentioning suicide to friends. In 1977, at age 22, he shot and killed himself with a .32 caliber pistol. The death later was re-ruled an accident because he was under the influence of quaaludes.
Tom Arnold was married to Rosanne Barr, who he met while working on her sitcom, "Rosanne." The two went through a high-profile and somewhat outrageous divorce. Arnold, who also hosted "The Best Damn Sports Show Period," talked openly about his drug addiction and said Owen Wilson can take the opportunity to turn his life around.
Comedian Andy Dick can always be seen on the gossip pages for outrageous behavior. In 1999, he drove his car into a pole, was arrested and pled guilty to felony cocaine possession, and two misdemeanors: possession of marijuana and possession of a smoking device. Recently he and fellow comedian Jon Lovitz got into an argument over the death of Phil Hartman.
Paul Reubens, aka Pee-Wee Herman, starred in "The Pee-Wee Herman Show" and a series of movies based on the off-beat character. In 1991, he was arrested for masturbating in an adult theater. In 2002, he was arrested on child pornography charges, but later the charges were reduced to a misdemeanor obscenity charge.