One of the most quoted movies of the 2000s is celebrating its 10th anniversary this week. Lindsay Lohan led the cast of this cult teen comedy, written by and co-starring "SNL" alum Tina Fey. Some of the other cast members, like Amanda Seyfried and Rachel McAdams, were relatively unknown at the time but have since gone on to superstardom, while others, such as Lohan, have faced setbacks over the years.
Lindsay Lohan -- ThenLohan was 17 when she was cast in the lead as Cady Heron, who tries to fit in with the popular Plastics clique during her first foray ever attending public school.
At the time of the shoot, the budding actress was known as a Disney child star, with appearances in the "Parent Trap," "Freaky Friday" and "Herbie" remakes.
Lindsay Lohan -- Now
As we've all seen, Lohan's career and reputation took a sharp decline in the years following the success of "Mean Girls." The Hollywood starlet has faced repeated run-ins with the law, dealt with substance abuse, attended rehab multiple times and served as constant tabloid fodder over the last decade.
She recently starred in a reality series on Oprah Winfrey's OWN Network, chronicling her struggles to stay sober while attempting to get her career back on track.
Lizzy Caplan -- ThenCaplan's breakout role came in the form of Janis Ian, an off-beat student who shared the same name as the popular singer-songwriter. Janis was a social outcast who wanted to get revenge on the trendy Plastics, although today her hipster-style would be considered more mainstream than misfit.
Lizzy Caplan -- NowCaplan has had a steady stream of roles. Some of her credits include "Cloverfield," "Hot Tub Time Machine" and "127 Hours." The now-31-year-old actress currently stars alongside Micheal Sheen in the Golden Globe-nominated "Masters of Sex."
Amanda Seyfried -- ThenSeyfried made her big-screen debut in "Mean Girls" as Karen, a member of The Plastics.
Amanda Seyfried -- Now
Seyfried's star-power has exploded in the years since her "Mean Girls" debut. Some of her big-budget credits include "Mama Mia!," "Dear John," "In Time" and "Les Miserables."
She's next set to star in Seth MacFarlane's "A Million Ways to Die in the West."
Daniel Franzese -- ThenLike many of the younger cast members, Franzese caught his big break in "Mean Girls," playing Janis Ian's best friend Damian. At one point, she memorably describes him as being "almost too gay to function."
Daniel Franzese -- NowFranzese has appeared in mostly comedic roles over the years.
In 2014, Franzese publicly came out as a gay man, penning an open letter to his "Mean Girls" character. Franzese thanked Damian for serving as a personal inspiration in his coming out process.
Jonathan Bennett -- ThenJonathan Bennett played Aaron Samuels, Cady's crush and Regina's ex.
Jonathan Bennett -- NowNow 32, Bennett has starred in mostly straight-to-DVD sequels, like 2007's "Dukes of Hazzard: The Beginning" and 2009's "National Lampoon's Van Wilder: Freshmen Year."
"Mean Girls" continues to be his best-known work.
Lacey Chabert -- ThenChabert, who had been known for her turn on TV's "Party of Five," co-starred as Plastics member Gretchen, definitely a follower and not a leader.
Lacey Chabert -- NowOver the last decade, Chabert has performed a number of vocal roles in video games and animated TV shows, although she still acts on-screen.
This handout photo came from the set of her new Hallmark movie, "The Color of Rain," set to debut May 31.
Rachel McAdams -- ThenThe meanest of them all. Who could forget McAdams' turn as the leader of The Plastics, Regina (which means "queen" in Italian).
Shrewd and conniving, Regina was Cady's ultimate nemesis.
Rachel McAdams -- Now
Like Seyfried, MacAdams has enjoyed a great deal of success since "Mean Girls."
She became a household name with the release of the ultimate tearjerker, "The Notebook," co-starring Ryan Gosling.
Other credits include "Wedding Crashers," "Red Eye," "Sherlock Holmes," "Midnight in Paris," "To The Wonder" and "About Time."
Amy Poehler -- Then
One of the funniest performances in the film came from Tina Fey's friend and former "SNL" co-star Amy Poehler, who played Regina's mom -- a woman trying way too hard to act like a teenager.
Amy Poehler -- Now
Poehler's career has certainly been on the rise lately.
She's the star of one of NBC's most popular sitcoms, "Parks and Recreation."
Tina Fey -- ThenFey wrote the "Mean Girls" screenplay, based on Rosalind Wiseman's non-fiction book "Queen Bees and Wannabees." She also co-starred as teacher Ms. Norbury.
Tina Fey -- NowFey went on to star in the hit sitcom "30 Rock" from 2006-2013. In 2011, Forbes deemed her TV's highest-paid actress.
She teamed up with Poehler again for 2008's "Baby Mama." The pair have also hosted the Golden Globes for the last two years.
Ana Gasteyer -- ThenAnother "SNL" alum, Gasteyer played Cady's mom.
Ana Gasteyer -- Now
Gasteyer stars on the ABC series "Surburgotry. " She will appear in the upcoming "Paul Blart: Mall Cop 2."
Tim Meadows -- Then
Yet another "SNL" alum, Meadows played the school's principal, Mr. Duvall, a love interest for Fey's character.
Tim Meadows -- Now
Meadows was the only cast member to return for the 2011 straight-to-DVD release "Mean Girls 2," which was poorly received.
His last film role was in 2013's "Grown Ups 2."