While only between 10 and 15 percent of the global population identifies as being left-handed, a seemingly disproportionate number of world leaders, artists and icons live their lives southpaw style. Take, for example, U.S. presidents.
President Obama is a proud lefty and he's far from alone. In fact, five of the United States' last seven presidents favored the less favored hand: President Clinton, President George H.W. Bush, President Reagan and President Ford.
Interestingly enough, Senator John McCain is also left-handed. So either way the 2004 election had gone, a lefty would have been Commander-in-Chief.
Prince William, Duke of Cambridge, is also a lefty, which works out nicely for the British royal family because he and Duchess Kate can both wave to well-wishers with their dominant hands.
Ned Flanders, the Simpsons' religious next door neighbor, is so rah rah about being left-handed that he quit his job in the pharmaceuticals industry and invested his life savings into "The Leftorium," a store in the Springfield Mall that specializes in products for lefties.
And Flanders isn't alone. Numerous characters on "The Simpsons" are shown writing with and favoring their left hands, including Bart Simpson, Marge Simpson, Mr. Burns, Seymour Skinner, Moe Szyslak, Martin Prince and Dolph Starbeam. All that lefty love is due to the fact that Simpsons creator Matt Groening is left-handed himself.
Historically, there has been a bit of stigma around left-handedness. For years, people believed the trait to be a sign of brain damage, disease or evil. In fact, the word for "left" in Latin derives from the same root as the word for "sinister." And that theory is not without its notable examples: the Boston Strangler, Jack the Ripper and Osama bin Laden were all lefties.
Don't try to pick that argument with lefty actress Julia Roberts, though. She played Erin Brockovich, so she's probably pretty formidable in a verbal battle.
Steve Jobs & Bill Gates
In recent years, psychologists have hypothesized that -- rather than being a sign of malady or evil -- being left-handed may actually be a sign of a strong right brain and, as such, superior language skills and creativity. The fact that Steve Jobs and Bill Gates are both lefties certainly supports that theory.
Rounding out the group of tech geniuses who changed the world with their left hands, Facebook founder and CEO Mark Zuckerberg is a southpaw as well.
Billionaire Oprah Winfrey is also a member of the southpaw club. And since women are statistically less likely to be left-handed than men, this is yet another quality that sets Oprah apart and makes the talk-show queen her OWN woman.
There may be "One Less Lonely Girl" because of Justin Bieber, but there's also one more lonely right-handed baseball mitt.
The Biebs is a lefty. Just look at the hand with which the Canadian pop star accepts awards.
In the film "Hellboy," the title character brandishes a gun with his left hand. Perhaps thats because the actor playing that character, Ron Perlman, is left-handed in real life.
Hollywood power couple Sarah Jessica Parker and Matthew Broderick are both left-handed. So, forget Ferris. In their household, right hands get the day off.
When Sir Paul McCartney took up the bass guitar as a child, he found it difficult to play right-handed. So, he reversed the strings and the rest is history. He now plays a true left-handed bass.
Left-handed guitar phenom Jimi Hendrix, on the other hand, played a right-handed Fender Strat, slung upside-down across his shoulders. He didn't even feel the need to restring it. Hendrix simply taught himself how to strum the strings in reverse order.
There are also a number of notable musicians, including Duane Allman, Barry Gibb and Paul Simon, who are left-handed by birth, but play their instruments righty.
Will Ferrell is part of a long list of left-handed comedians. Perhaps that's why his "Zoolander" character, Mugatu, holds his evil dog in his left hand.
When pop star Lady Gaga sings about being "Born This Way," she could very well be talking about being left-handed.
Supreme Court Justice Ruth Bader Ginsburg
In his book "Right-Hand, Left-Hand," University College London psychologist Chris McManus states that lefties have made up a disproportionately larger number of high achievers throughout history. Perhaps that explains why lefty Supreme Court Justice Ruth Bader Ginsburg has presided on the nation's highest court for years.
There are a number of things that make Caitlyn Jenner unique. She holds a gold medal in the Olympic decathlon. She embarked on arguably the most public transition in history. And, last but not least, she's a lefty.
Jerry Seinfeld & Jason Alexander
There are a number of prominent comedians who prove that the dexterous road less taken may just be the funnier path. "Seinfeld" funny men Jason Alexander and Jerry Seinfeld are both left handed, as are Trey Parker, Jason Sudeikis, Ben Stiller, Seth Rogen and Tim Allen.
When Jon Stewart jotted down all those "Daily Show" jokes for 16 years, he did it with his left hand.
While the sport of baseball has seen its fair share of southpaw superstars (Ty Cobb, Ted Williams, Lefty Grove, Sandy Koufax, Barry Bonds, Warren Spahn, etc.), its most famous left-handed slugger is, without question, the Sultan of Swat.
When Hollywood beauty Angelina Jolie signs autographs for fans, the "Maleficent" star does it with her left hand.
Jennifer Lawrence is left-handed, but as this picture makes apparent, Katniss Everdeen is not.
When Edwin E. "Buzz" Aldrin, Jr. walked on the surface of the Moon during the Apollo 11 lunar mission in 1969, it was one small step for man... one giant leap for lefties.
Longtime "Tonight Show" host Jay Leno is a lefty as well.
The Real Slim Shady may be underhanded, but Marshall Mathers is left-handed.
While the characters that made him famous in "Speed" and "The Matrix" trilogy were right-handed, Keanu Reeves is a lefty.
Here, he signs the hood of an Acura at the 2015 Sundance Film Festival, proving that he picks up a pen with a different hand than he shoots a gun on-screen.
The charcter of Link from the popular game "Legend of Zelda" is most often pictured wielding a sword with his left hand.
"Saturday Night Live" alum Tina Fey is left-handed as well, proving that having physical quirks may better prepare people to execute quirky humor.
Renowned singer and actress Judy Garland was left-handed, leaving moviegoers everywhere with the impression that, "There's no place like home," and no star like a lefty.
British Chef Gordon Ramsey is a lefty. And judging from all of his Michelin stars, that dominant left hand may just give him an upper hand in the kitchen.
In his book "The Puzzle of Left-handedness," author Rik Smits presents the theory that lefties derive from identical twins. More specifically, because identical twins often have mirror traits, Smits pontificates that lefties are the result of these embryos splitting in the womb.
Perhaps that explains why Mary-Kate Olsen is a lefty and her sister, Ashley, is a righty. Whatever the reason, though, it's the perfect arrangement for signing autographs next to your twin.