From right-wing criticism to silly revelations that the division is sort of diagonal leaving Los Angeles (which is actually in southern California) off the list - and even random thoughts of Tupac - here's what nine of them had to say...
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Geography fail
"The secession plan for South California would put LA in 'north' California. Geography is clearly not Jeff Stone's best subject." -xhurwitz
Credit: Twitter
Ironic
"How ironic if South California was declared a separate state then broke off in an earthquake and drifted out to sea. #JustStopRightThere" -LouBrutus
Credit: Twitter
South California tourism woes
"'Hey kids! This year, let's take a vacation to the 51st state, South California!' -Worst dad ever 40 years from now" -Racheldoesstuff
Credit: Twitter
You mean West Arizona
"South California? CA is too liberal for SoCal conservatives? Be real and name the new state West Arizona. Notice which CA gets the border?" -TonyBadilla
Credit: Twitter
What about Baja?
"Calif. Republicans want South California to be the 51st state. But there already is one. It's called Baja..." -RogerBlack
Credit: Twitter
On commuting
"man, south california sounds like a stupid idea but i like the idea of being able to say i ~cross state lines to go home on weekends lol" -rosysayshi
Credit: Twitter
Canadia?
"america already has a 51st state: Canadia. We don't need 'South California.'" -gmcgirt
Credit: Twitter
Tupac, you listening?
"If we seriously going to make #SouthCalifornia a state then #2PAC must come back and be the governor. RT if you agree!" -KingJ323
Credit: Twitter
Out of boredom
"Congress wanna turn California into 2 states .... California and South California ...smh #ThingsWhitePplDoWhenBored" -crystal_love10