She's the youthful and sexy grandmother in the surprise hit "The 40-Year-Old Virgin." She's a wisecracking federal agent teamed with Sean Penn in "The Interpreter." And in the critically-acclaimed "Capote," she's novelist Nelle Harper Lee, the lifelong friend who understands Truman Capote only too well.
More from CBSNews.com on Catherine Keener and on the Oscars ...
The nomination for best supporting actress in "Capote" is Keener's second. She also was nominated for her performance as Maxine in the truly strange 1999 fantasy movie, "Being John Malkovich."
Born in Miami on March 26, 1960, Keener has a long string of credits in small independent movies — and has had major roles in some clunkers, such as 2002's "Death to Smoochy."