He died in Palm Beach after a long battle with leukemia, Red Sox spokeswoman Pam Ganley said.
Gowdy made his broadcasting debut in 1944 and went on to call 13 World Series and 16 All-Star games.
In 1951 Gowdy became main play-by-play voice on the Red Sox broadcast team. He left the Red Sox in 1966 for a 10-year stint as "Game of the Week" announcer for NBC.
He was also the longtime host of the "American Sportsman" series.
"He's certainly the greatest play-by-play person up to this point that NBC sports has ever had," NBC Universal Sports chairman Dick Ebersol said Monday.
"He literally carried the sports division at NBC for so many year on his back. ... He was a remarkable talent and he was an even more remarkable human being," Ebersol said.