The 51-year-old Hamilton, who won the 1984 Olympic gold medal and is a four-time world champion, was diagnosed with testicular cancer in 1997 and with a noncancerous brain tumor in 2004.
For the last nine years, Hamilton has staged "An Evening with Scott Hamilton and Friends," and on Nov. 7 he will skate in the event at the Quicken Loan Arena. Hamilton's show has raised $10 million for Hamilton's CARES Initiative at the Clinic's Taussig Cancer Institute.
The story was first reported by the Cleveland Plain Dealer.
"Cleveland Clinic has been a part of so many major life moments for me," Hamilton said Thursday. "The medical team successfully treated me for testicular cancer and has been guiding me through my journey with a brain tumor."
"We've celebrated many happier milestones together, too; from proposing to my wife to finding out we were pregnant," he added. "That's why it feels so right to be marking my return to the ice surrounded by the very people who brought me back to such great health at age 51 and have been with me through all of the ups and downs along the way."
Hamilton, who grew up in Bowling Green, Ohio, was treated at the Cleveland Clinic for his cancer and tumor. He now lives in Nashville, Tenn.
Joining Hamilton in the show that will salute music of the Beatles will be the Cleveland Pops Orchestra and the rock band Cheap Trick.