"They just hang in there and all of a sudden, they have the ability to turn around the game," Pitino said Tuesday on "CBS This Morning."
Pitino also vowed to follow through on a mid-season promise he made to his players to get a tattoo if Cardinals won the national championship.
"I said it ... not believing this was going to be a reality but I am going to get it. I'm a man of my word. I'm going to get it on my left shoulder," Pitino explained. "It will be a cardinal and it will say 2013 champions."
Pitino also addressed his player Kevin Ware's gruesome leg injury early in the tournament, saying that he knew the team was extraordinary when he witnessed the "spontaneity of emotion when Kevin Ware got hurt."
"This was the best chemistry I've ever had of any basketball team," he added.
Louisville junior Luke Hancock -- who was named the Final Four's Most Outstanding Player -- appeared on "CBS This Morning" alongside Pitino and was the first player to rush to Ware's side when he went down with a broken leg.
"I just went out there and I felt like I didn't want him to be alone," Hancock said. "I just wanted to be next to him and tell him it was going to be alright and that we were there for him."