Jeanine Harrington, 25, was arraigned in Brooklyn Criminal Court on charges of second-degree murder and criminal possession of a weapon — the vehicle, the Brooklyn district attorney's office said.
Harrington, who was represented by a court-appointed attorney, was jailed without bail.
She struck Jeffrey Moore, 47, in Brooklyn's Bedford-Stuyvesant neighborhood around 6 a.m. Tuesday, police and the DA's office said.
Witnesses said Harrington drove the wrong way down a street and over a curb to hit him, then backed up and ran over him again. After pulling the crushed bike out from under the SUV, she drove off, according to witnesses. Police found the vehicle a few blocks away.
Harrington, who is pregnant, was driving her other lover's SUV, according to the New York Daily News.
Cops tracked down Harrington after finding the abandoned SUV and tracing it to Michael Cooper, her live-in lover, the Daily News added.
"What kind of heart do you have to do something like that?" Moore's sister, Jade Oliver, said after he was pronounced dead on arrival at Brookdale University Hospital and Medical Center.
Oliver said her brother and Harrington had a rocky relationship laced with jealousies.
"I told him to leave that woman alone," said Oliver, 57, who said Moore had once been an amateur boxer.
Neighbors and friends propped candles outside Moore's Brooklyn home, writing such messages as "I'm so sad that you left us like this."
"He always had a nice, kind word to say," said Toni Favorite, who said Moore often walked her home to make sure she got there safely. "You know, he made us feel protected."