Devin West ran for 252 yards and Corby Jones accounted for three scores despite a sore toe, leading No. 21 Missouri past Iowa State 35-19 on Saturday.
Iowa State (2-4, 0-3) also was slow to the corner on several other plays, including a Jones-to-John Dausman swing pass that Dausman turned into a 64-yard touchdown.
West's total was second only to the 319 yards he gained against Kansas earlier this year. He carried a career-high 40 times, scored on runs of 1 and 10 yards and caught a 15-yard touchdown pass from Jones with 3:56 left to secure the victory.
That last touchdown capped an eight-minute, 55-second drive during which West carried 14 times for 81 yards.
Jones had practiced sparingly because a sore big toe on his left foot and was far from perfect. He overthrew a wide open receiver, made two bad pitches to West and had the ball stripped while being sacked.
But he was nimble enough to fool Iowa State on a 15-yard touchdown run on a bootleg, and he set up West's second touchdown with a 40-yard completion to Kent Layman. He finished 9-for-15 passing for 176 yards with no interceptions.
Iowa State went 72 yards in 13 plays on the game's opening series to take a 7-0 lead on Darren Davis' 2-yard TD run. Davis finished with 107 yards in 30 carries.
Missourithen kept the Cyclones out of the end zone until late in the game and took control behind West and Jones.
Four plays after Davis scored, Missouri was at its own 36 when Jones swung a short pass out to Dausman, who sped untouched down the left sideline for a touchdown.
Jones used some sleight-of-hand to put the Tigers ahead 14-7 early in the second quarter. He faked a handoff to West, then sprinted out to his right and went 15 yards for a touchdown, running over efensive back Breon Ansley at the 1 and knocking him into the end zone. Wade Perkins' interception set up that touchdown.
The Tigers scored again after Iowa State's Adam Runk muffed a punt. Julian Jones recovered for Missouri at the Iowa State 34 and West scored on a 1-yard run seven plays later.
The Tigers led just 21-13 when they went 90 yards in nine plays for a touchdown midway through the fourth quarter. Jones' pass to Layman took the ball to the Iowa State 24 and West scored from the 10 on a pitchout from Jones.
Iowa State got a late TD on Todd Bandhauer's 26-yard pass to Michael Brantley. Bandhauer was intercepted three times, however, and overthrew a wide open Chris Anthony in the end zone in the second quarter when the Cyclones trailed just 14-7. They had to settle for Jamie Kohl's 30-yard field goal.
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