At least 20 people were killed in a missile strike near the Afghan border on Sunday, state-run Pakistan Television said.
The strike destroyed the house of a suspected militant leader, according to a local tribesman.
Seven missiles were fired in the strike in the tribal area of South Waziristan, the television report said.
The report did not indicate where the missiles came from, but U.S.-led coalition forces based in neighboring Afghanistan have launched attacks inside the Pakistani border in the past.
Pakistan has been battling Islamic militants linked to al Qaeda and the Taliban in its regions bordering Afghanistan. The U.S. considers the country's effort vital to the war on terrorism.
The missiles were fired by an unmanned drone, local tribesman, Rahim Khan, told The Associated Press.
At least two hit and destroyed the home of a local militant leader and Taliban sympathizer who goes by the single name Noorullah, Khan said.