The 76-year-old host of CNN's "Larry King Live" filed Wednesday to end the couple's nearly 13-year marriage, citing "irreconcilable differences." He married Shawn Southwick-King in a hospital room in 1997 three days before surgery to clear a clogged blood vessel.
The couple have two sons, ages 11 and 9. King is seeking joint custody of the boys. He is also asking a court not to award Southwick-King, 50, any spousal support.
"His major concern is the welfare of his children," said Howard Rubenstein, a spokesman for King.
He said Southwick-King filed for divorce moments after King's filing. Her filing was not immediately available.
Rubenstein said the talk-show host would not comment further on the divorce.
The filing was first reported by celebrity Web site TMZ.com.
King's nightly news and interview show has been a CNN mainstay for nearly 25 years.
He and Southwick-King started house-hunting in California shortly after their marriage and lived in Beverly Hills. He is a Los Angeles Dodgers season ticket-holder and announced the start of the team's home opener to fans Tuesday.
King has three children from previous relationships.