Concert promoters AEG Europe said Wednesday the star of such musicals as "Mary Poppins" and "The Sound of Music" will appear at London's 02 Arena on May 8.
Andrews had non-cancerous throat nodules removed in 1997. The operation initially left her unable to sing.
Andrews has since starred in "The Princess Diaries" and was the voice of Queen Lillian in the "Shrek" film series.
Tickets go on sale Thursday.
Andrews says in a statement "to perform once again in my homeland on the London stage will be a wonderful moment - it is where it all began for me."