"We got on great," Jolie says of her "Mr. and Mrs. Smith" co-star in the July issue of Marie Claire. But as far as anything past friendship, she says, "absolutely not."
"To be intimate with a married man, when my own father cheated on my mother, is not something I could forgive," she says. "I could not, could not look at myself in the morning if I did that."
Pitt, 41, separated from Jennifer Aniston in January after 4 1/2 years of marriage. Aniston, 36, filed for divorce in March, citing irreconcilable differences.
Tabloids immediately speculated on the Jolie factor. When photos of Pitt, Jolie and her 4-year-old son Maddox walking together on a beach in Africa were published in April, the tabs took it as proof of a romance.
Instead, Jolie says she's single, and concentrating on her son.
"I am not dating anybody. I think the next man I get involved with would have to become Mad's father, and that's a high bar as far as I'm concerned. I'm not anticipating that coming anytime soon."
Her marriages to Jonny Lee Miller and Billy Bob Thornton ended in divorce.
The 29-year-old actress has also continued her spirited support of African refugees as a goodwill ambassador for the United Nations.
"I have seen progress in the issues that I care about, and I've started to see how I can make a difference."