NBC said Monday that Mrs. Obama is set to respond to 10 "rapid-fire questions" in a comedy bit with Leno. She'll participate via satellite from Washington.
Leno's Q&A routine with celebrities and newsmakers has featured Justin Timberlake, Sen. John McCain and LeBron James, among others.
The first lady is to appear Friday on "The Jay Leno Show." Colin Firth is the scheduled guest.