The 13th annual Webbys were announced Tuesday. A special achievement award was also given to Nine Inch Nails frontman Trent Reznor, who released his 2008 album, "The Slip," as a free download.
Seth MacFarlane, the "Family Guy" creator, was honored as film and video person of the year for his Web franchise "Cavalcade of Cartoon Comedy."
Nation Public Radio led winners with seven awards, including wins for its music division, mobile news and podcasts. The New York Times' online unit - last year's Webby leader - earned six awards, the same total that NBC.com also received.
Twitter, the fast-growing microblogging site, won the Webby for breakout of the year.
Two well-known comedians were also singled out.
Sarah Silverman was honored as best actress for her performance in the viral video "I'm ... Matt Damon" and for her contribution to a voting initiative video. Lisa Kudrow won for outstanding comedic performance as the star of the series "Web Therapy" on lstudio.com.
The awards will be presented in New York on June 8, hosted by Seth Meyers ("Saturday Night Live"). The Webbys are known for their brief acceptance speeches, where winners are limited to five words. (Stephen Colbert, a special achievement winner last year, said: "Me. Me. Me. Me. Me.")
Since "Late Night With Jimmy Fallon" began in early March, the comedian has augmented his NBC broadcast with Web videos, blogging and tweeting on Twitter.
Reznor's online fervor was evident Sunday, when he posted in a Nine Inch Nails forum that he was frustrated with what he called Apple's inconsistent standards. He criticized the company for not making the band's album "The Downward Spiral" available on its iPhone app even though it's for sale on iTunes.
The Onion won for best humor Web site and its television news parody, Onion News Network, won for best writing. The Huffington Post won for best political Web site.
Best individual comedy short went to "Prop 8: The Musical," a video from the Will Ferrell co-founded site FunnyOrDie.com. The star-studded video (Jack Black, Neil Patrick Harris) suggested that gay marriage (which was then being voted on in California as Proposition 8) would save the economy.
Best comedy series went to "Childrens' Hospital," the medical drama parody for TheWeb.com by Rob Corddry ("The Daily Show").
PBS won four Webbys, including best news and politics series for its "Frontline/World iWitness." Others with multiple awards included the BBC, Sundance Channel, YouTube Live, Next New Networks and Wired.com.
The Webbys are presented by the International Academy of Digital Arts and Sciences, a 550-member group of Web experts. Every category has two winners: one picked by the Webbys and the other chosen by online voting.
By Jake Coyle