CBS won't comment on the longtime host's possible successor, but social media lit up shortly after Letterman announced the news on Thursday, saying, "The man who owns this network, Leslie Moonves, he and I have had a relationship for years and years and years, and we have had this conversation in the past, and we agreed that we would work together on this circumstance and the timing of this circumstance. And I phoned him just before the program, and I said 'Leslie, it's been great, you've been great, and the network has been great, but I'm retiring."
Who do you think should take over the "Late Show" when David Letterman retires?
Or maybe Louis C.K.? After all, he did have a multiple-episode arc on his FX series, "Louie," all about auditioning to fill Letterman's shoes.
Or maybe it's time for a woman to grace a major network in the late-night space. Chelsea Handler is expected to leave "Chelsea Lately" on E! after eight years. Or, if Tina Fey came on board, the one-time "SNL" star could follow her former cast mate Jimmy Fallon's footsteps into the late-night world.
Who do you think should replace Letterman? Take our poll and give us your picks in the comments below.