Polian told the station that Clark will meet with doctors on Thursday to determine the extent of the injury and how long he will be sidelined. Coach Jim Caldwell would only confirm on Thursday that Clark was being evaluated.
Peyton Manning has combined with Clark to form one of the most prolific quarterback-tight end combos in NFL history. Clark ranks third on the team with 37 catches for 347 yards this season after catching 100 passes for 1,106 yards and 10 touchdowns last season.
The team re-signed tight end Gijon Robinson on Wednesday, fueling speculation that Clark's injury was severe.
Polian also said during the taping of his weekly TV show that the bye week is coming at just the right time, WISH reports.
"The most important thing is try to get to the bye week and then get as many people healthy as we can," Polian said. "I can't ever remember a time that we have had, this early, as many injuries as we have had. But we'll fight our way through it, and thank goodness we are not playing this weekend so everybody can get rested up and healed up and we'll get ready for the second half."