The series, which tapes at the CBS Broadcast Center in New York, has delivered moderate ratings since its debut in September, averaging a 0.9 in households this season.
The decision was made by Telepicture Productions, which produces "Bethenny," after a deal with affiliates failed to be reached.
"I had a blast doing this show with Telepictures," Frankel said. "My entire staff worked so hard and made everyday so much fun. I am thankful for the experience and for all my fans who tuned in every day."
A new talk show hosted by Meredith Veira is expected to take over Frankel's soon-to-be-empty timeslot in most markets.