The sign along an Interstate 70 business loop in Grand Junction drew criticism from local Republicans and Democrats.
The artist, Paul Snover, of nearby Loma, says he has received what he calls "very hateful" emails and phone calls.
Snover has said he couldn't reveal who paid for the billboard.
The Daily Sentinel said he couldn't be reached Friday to explain why it was removed.
The owner of a company where the sign was erected says she's glad it's gone because it attracted such a crowd.