The 33-year-old "My Name is Earl" co-star was arrested Jan. 5 after Santa Monica police say she was stopped for a traffic violation. She was released after posting $15,000 bail.
Deputy City Attorney Melanie Skehar says Pressly was charged Tuesday morning with driving under the influence and having a blood alcohol content of .20 or higher.
An e-mail message for Pressly's publicist was not immediately returned.
The charges were first reported Tuesday by celebrity website TMZ.