The plane was based at nearby Dorval airport and was headed to Ontario, according to the Royal Canadian Mounted Police. They had few other details.
"We were told there was a technical problem," said Sgt. Marcel Parent. He said the weather did not appear to be a factor.
It was cloudy, but not raining Thursday morning at the airport, 25 miles northwest of Montreal. When the crash occurred at around 7:35 a.m. EDT.
Smoke could be seen billowing from the aircraft at the end of one of Mirabel's runways, and emergency vehicles surrounded the wreck.
The plane was carrying two crewmembers and 10 passengers.