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Drew Brees was pulled at halftime with a rib injury after passing for just 76 yards and one touchdown but Alvin Kamara scored three times and New Orleans' defense largely stifled San Francisco to help the Saints secure a 27-13 victory.
The San Francisco 49ers heard all about the Super Bowl runner-up curse before the start of this season, but the Niners felt they had the ingredients to buck that trend.
The San Francisco 49ers on Monday placed receiver Kendrick Bourne back on the COVID-19 list three days after removing him.
After a positive COVID-19 test took away four players from the San Francisco 49ers before their game against the Green Bay Packers, those same players tested negative for the virus twice, while one Packer was tested positive after the game.
Aaron Rodgers threw for 305 yards and four touchdowns and the Green Bay Packers overwhelmed the undermanned 49ers 34-17 on Thursday night.
Mere hours before the San Francisco 49ers take on the Green Bay Packers, 49ers wide receiver Kendrick Bourne tested negative for COVID-19, throwing his positive test from the day before into doubt.
The San Francisco 49ers announced Wednesday afternoon that the team would face the Green Bay Packers without LT Trent Williams and WR Brandon Aiyuk because they had close contact to WR Kendrick Bourne, who tested positive for COVID-19.
In a San Francisco 49ers regular season already awash with injuries, head coach Kyle Shanahan is now facing the very real possibility that starting quarterback Jimmy Garoppolo has been lost for the remainder of the year.
As the NFL Trading Deadline came and went Tuesday afternoon, the San Francisco 49ers announced they have waived former second round pick Dante Pettis, who never fulfilled the potential on the professional level that he achieved as star receiver at the University of Washington.
In a season marred by injuries, the San Francisco 49ers were dealt two more serious blows Monday as both star tight end George Kittle and starting quarterback Jimmy Garoppolo have again been sidelined and will miss games.
Coming off a 37-27 loss to the Seattle Seahawks, the San Francisco 49ers Monday traded away injured linebacker Kwon Alexander to the New Orleans Saints, according to several news sources.
The Seattle Seahawks rebounded from their first loss of the season with a resounding 37-27 win over the San Francisco 49ers on Sunday.
This week, the San Francisco 49ers don't need loud piped in noise at practice, silent counts and other preparations that usually accompany a trip to Seattle.
There's no denying there is a certain mentality that permeates the San Francisco 49ers lockerroom. It's raw, physical and creates an aggressive in-your-face mindset when the team takes the field.
Jeff Wilson Jr. rushed for a career-high three touchdowns and 112 yards before leaving with an ankle injury and the 49ers dominated in a 33-6 win over the Patriots on Sunday.
Nick Kurtz homered for a third straight game, hitting a go-ahead three-run shot in the fifth inning and the Athletics beat the San Francisco Giants 5-2 on Friday night.
Rickea Jackson knocked down a 3-pointer with 1:41 remaining to help clinch it and scored 18 points, Skylar Diggins added 15 points, seven assists and five assists, and the Chicago Sky beat the Golden State Valkyries 69-63.
Shohei Ohtani tossed four-hit ball over seven shutout innings, leading the Los Angeles Dodgers to a 4-0 win over the San Francisco Giants.
The San Francisco 49ers will host the Minnesota Vikings for a game in Mexico City this fall, National Football League officials confirmed Wednesday.
Harrison Bader and Eric Haase hit back-to-back homers for the San Francisco Giants in the fifth inning, leading them to a 6-2 win over the Los Angeles Dodgers.
Charle Young, an All-Pro tight end who helped the San Francisco 49ers win their first Super Bowl title, has died.
Jason Collins, the NBA's first openly gay player, who went on to become a pioneer for inclusion and an ambassador for the league, has died, his family announced Tuesday.
Steve Kerr has signed his new two-year contract to remain as coach of the Golden State Warriors.
Memphis Grizzlies forward Brandon Clarke has died at the age of 29, the team announced.
Pacific Gas & Electric Company is warning residents in several Northern California counties that power shutoffs will be likely starting later this weekend.
Nick Kurtz homered for a third straight game, hitting a go-ahead three-run shot in the fifth inning and the Athletics beat the San Francisco Giants 5-2 on Friday night.
A series of retail thefts in the South Bay involving boxes of golf balls resulted in the arrest of a suspect earlier this month, police said Friday.
Fire agencies across the North Bay are preparing for elevated wildfire danger this weekend as forecasters warn of strong winds and low humidity - conditions that often signal the start of fire season in Sonoma, Napa, and Marin counties.
Traffic is recovering on Interstate 80 in Solano County on Friday afternoon after an incident involving a person barricaded in a vehicle.
Bay Area fans of the K-pop superstar group BTS flocked swarmed Stanford University more than 24 hours before the first of three shows on campus.
For San Francisco-based rapper Aft, stoops were a part of his upbringing in the Fillmore District.
Police in San Francisco on Thursday announced the recent arrests of four people suspected in dozens of retail thefts targeting stores and coffee shops around the city.
A San Francisco Bay Area father has pleaded no contest to shooting at a group of teenagers who egged his home during a prank last year.
Some business owners said they worry that if it goes through, it could have devastating impacts to an already struggling industry.
Police in Concord said they are searching for several suspects following a smash-and-grab robbery at a mall Wednesday afternoon, in which an employee was pepper sprayed.
San Leandro Police Chief Angela Averiett has been placed on administrative leave after being charged in a 2025 hit-and-run collision, authorities said on Wednesday.
A family injured in a massive explosion in their Hayward home from a gas leak in December 2025 filed a lawsuit against Pacific Gas and Electric and Alameda County on Wednesday, their attorneys said.
Authorities in the East Bay have charged two men for allegedly organizing a sideshow in Oakland that broke out as internet sensation IShowSpeed was visiting the area.
Oakland's housing market is seeing some of the steepest price declines in the country, with home values falling sharply as sellers, buyers and real estate agents navigate a difficult market.
A series of retail thefts in the South Bay involving boxes of golf balls resulted in the arrest of a suspect earlier this month, police said Friday.
Police in Santa Clara released additional details in connection with a deadly shooting and house fire last week, saying the suspect shot his estranged brother before setting the fire.
Authorities in the South Bay have identified two people who died in a deadly shooting and suspicious fire that took place in a Santa Clara neighborhood last week.
A portion of a South Bay park is closed and an investigation is underway after a dog was sickened by suspected rat poison.
Three men from Tennessee have been indicted on federal charges, including attempted kidnapping, in connection with an alleged crime spree targeting cryptocurrency owners in California.
Fire agencies across the North Bay are preparing for elevated wildfire danger this weekend as forecasters warn of strong winds and low humidity - conditions that often signal the start of fire season in Sonoma, Napa, and Marin counties.
Residents living near the Charles M. Schulz Sonoma County Airport say the skies above their neighborhoods are getting louder as passenger traffic and jet service continue to grow.
Health officials in Napa County are warning the public not to eat wild mushrooms after three people were poisoned.
At least one person has died in a multi-vehicle crash in Napa County on Tuesday afternoon involving two vehicles and a motorcycle, authorities said.
A suspect driver surrendered to police following a fatal hit-and-run crash that killed a wheelchair user in Santa Rosa on Monday, the department said Tuesday.
Nick Kurtz homered for a third straight game, hitting a go-ahead three-run shot in the fifth inning and the Athletics beat the San Francisco Giants 5-2 on Friday night.
Rickea Jackson knocked down a 3-pointer with 1:41 remaining to help clinch it and scored 18 points, Skylar Diggins added 15 points, seven assists and five assists, and the Chicago Sky beat the Golden State Valkyries 69-63.
Shohei Ohtani tossed four-hit ball over seven shutout innings, leading the Los Angeles Dodgers to a 4-0 win over the San Francisco Giants.
The San Francisco 49ers will host the Minnesota Vikings for a game in Mexico City this fall, National Football League officials confirmed Wednesday.
Harrison Bader and Eric Haase hit back-to-back homers for the San Francisco Giants in the fifth inning, leading them to a 6-2 win over the Los Angeles Dodgers.
A series of retail thefts in the South Bay involving boxes of golf balls resulted in the arrest of a suspect earlier this month, police said Friday.
Kars4Kids is banned from using its ads in California after a court found that the funds from donated cars were used for teenagers' international trips and a $16.5 million building in Israel.
Police in Santa Clara released additional details in connection with a deadly shooting and house fire last week, saying the suspect shot his estranged brother before setting the fire.
Police in San Francisco on Thursday announced the recent arrests of four people suspected in dozens of retail thefts targeting stores and coffee shops around the city.
A San Francisco Bay Area father has pleaded no contest to shooting at a group of teenagers who egged his home during a prank last year.
AI companies are recruiting a wide range of temp workers, from writers to wine enthusiasts, for hourly-paid gigs to help train their language models.
The delegation of business leaders underscores the deep ties many major U.S. companies maintain with China despite years of trade tensions.
Three men from Tennessee have been indicted on federal charges, including attempted kidnapping, in connection with an alleged crime spree targeting cryptocurrency owners in California.
A hacking group named ShinyHunters claimed responsibility for the Canvas breach and threatened to leak data involving 275 million individuals if schools did not pay a ransom.
GameStop CEO Ryan Cohen had argued that his company's retail locations would help eBay build a "national network."
California public health officials said on Wednesday that they have identified a fifth resident who may have been exposed to the Andes hantavirus due to the outbreak on the MV Hondius cruise ship.
Health officials in Napa County are warning the public not to eat wild mushrooms after three people were poisoned.
A Texas couple is filing a lawsuit accusing the AI company of guiding their teenage son in using drugs, resulting in a fatal overdose.
A Sacramento County resident is among four Californians being monitored for possible exposure to the Andes hantavirus linked to a deadly cruise ship outbreak, state health officials announced.
San Francisco Bay Area health officials provided an update on a resident who was exposed to the hantavirus during a cruise in the Atlantic, adding that the risk to the public remains low.
The Supreme Court on Friday rejected a bid by Virginia Democrats to revive its new voter-approved congressional map that was drawn to advantage the party for the upcoming midterm elections.
President Trump's trip to China could bolster economic relations, but failed to deliver a breakthrough deal, some trade and energy experts said.
Steve Large breaks down the California governor's debate in San Francisco.
Top gubernatorial candidates faced off in a debate hosted Thursday by CBS News California and the San Francisco Examiner.
Top gubernatorial candidates met onstage Thursday at a debate hosted by CBS News California and the San Francisco Examiner.
Jason Collins, the NBA's first openly gay player, who went on to become a pioneer for inclusion and an ambassador for the league, has died, his family announced Tuesday.
Philz Coffee will once again sport the Pride flag at its cafés after a directive to have them and other flags removed created a backlash.
The Trump administration agreed to restore the Stonewall National Monument's Pride flag in Greenwich Village after it was removed.
Philz Coffee's move to remove the Pride flag and all other flags from their stores is brewing up some strong reaction.
Transgender women athletes are now excluded from women's events at the Olympics after the IOC agreed to a new eligibility policy on Thursday.
Bay Area fans of the K-pop superstar group BTS flocked swarmed Stanford University more than 24 hours before the first of three shows on campus.
City officials in Elk Grove were finalizing preparations on Friday for a visit by country superstar Luke Bryan and an expected attendance of over 20,000 of his fans on Saturday.
For San Francisco-based rapper Aft, stoops were a part of his upbringing in the Fillmore District.
The Library of Congress revealed this year's list of 25 recordings to be preserved for future generations on the National Recording Registry.
Authorities in the East Bay have charged two men for allegedly organizing a sideshow in Oakland that broke out as internet sensation IShowSpeed was visiting the area.
Ever since the COVID-19 pandemic, the Oakland Unified School District has seen an alarming spike in the number of unhoused students in the school system who deal with a host of challenges far beyond what most children face.
Meteorologist and CBS News Bay Area's resident pilot Lt. Jessica Burch got a treat during Fleet Week, taking to the skies with one of the Blue Angels.
A Bay Area man discovered his devastating loss left him with a new opportunity to rethink how he lives -- follow his journey in virtual reality, 360-degree video.
A groundbreaking medical study involving the UCSF Medical Center has shown some colorectal cancer patients can safely skip radiation treatment and enjoy a potentially higher quality of life.
Every day, San Francisco bar pilot Captain Zach Kellerman goes through what might just be the world's most dangerous commute.
A new partnership between Santa Clara University and Sutter Health will create the first new medical school in the Bay Area in more than a century and could reshape the future of healthcare in California. Len Ramirez reports.
Three men from Tennessee are accused of traveling to the Bay Area to kidnap wealthy cryptocurrency holders. Katie Nielsen reports on the home invasions and why crypto is such an attractive target.
Gary Montrezza, the CEO of Pathway Society, is pushing himself to the limit to save his nonprofit, an organization that helps people transitioning out of prison and substance abuse. Len Ramirez reports.
Meteorologist Darren Peck says strong winds will create elevated fire danger inland and hazardous beach conditions over the weekend.
More radiological material was found at the former Hunters Point Naval Shipyard in San Francisco near where new homes are being built. Anne Makovec reports.
In 2025, KPIX is moving to a new community service award: the CBS News Bay Area Icon Award. Submit nominations for an outstanding community hero at kpix.com/icon.
It's the most wonderful time of the year for a South Bay woman who has played Mrs. Claus for more than 40 years for the children of North San Jose's Alviso District.
For residents of the Oakland Hills, the prospect of another wildfire always remains a concern. This week's Jefferson Awards winner has made it his mission to make the hills and other high-risk areas safer.
In East Palo Alto -- where state education numbers show more than nine in ten public school students are low income and more than half are English learners -- many are finding hope and connection at the Boys & Girls Clubs of the Peninsula.
This week's Jefferson Award winner is Army veteran who continues to live a life of service into his 80s, by feeding hundreds of San Francisco families a week.
A Bay Area man who overcame tremendous obstacles to excel in school has made it his mission to gear up other students for success in the classroom and in life.
For Students Rising Above scholar Josh Collins it took moving across the country to realize the value of his Bay Area family.
Samir Hooker had to grow up fast after his stepfather was shot dead 12 years ago. Now he is watching over his mom and sister while attending UC Berkeley.
It's hard enough to graduate from one of the most prestigious schools in the country when you're the first in your family to go to college. Imagine doing that while you're also trying to protect your parents from being deported?
Some students who are the first in their families to go to college face the challenge of balancing a rigorous academic load while still working to help support their family back home.
