Watch CBS News
Points could be hard to come by as San Francisco - winner of 10 of 12 against division opponents - squares off against the offensively-challenged Arizona Cardinals, who are hoping to avoid a fourth consecutive loss.
Find which tailgating party fits your taste and have some fun at your next 49ers game.
The Monday Night Game between the Cardinals and 49ers will go far in determining the eventual NFC West winner. Both teams are healthy for the most part, but the Cardinals have so many players banged up, that they will be in trouble if any injuries pop up in the course of the game. The biggest concern for Arizona will be the health of their quarterback who comes into the game already nicked up, and with an offensive line that has allowed the most in the NFL in sacks.
The Monday Night Game could be a hard fought game coming down to execution and which team makes the first big play, or can turn into a blowout. The Cardinals will hope that thier defense can keep them close enough for Larry Fitzgerald to make an impact, while the 49ers look to continue their winning ways and take control of the division.
The San Francisco 49ers defense has been the face of the team, and most of the attention has gone to the front seven. However, the secondary is a key reason they have the top-rated defense in the league.
Division rivals need no reason to dislike each other, and the 49ers and Seahawks have added fuel to the fire. After the teams recent match-up, 49ers head coach Jim Harbuagh questioned some of the play in the Seattle secondary that may have been overly physical, and this resulted in a war of words between the two teams. However, the end result will only help out San Francisco.
In a sport that puts so much focus on winning and losing, Chris Culliver of the San Francisco 49ers is not the norm. The young cornerback as been close to death, is just happy to be alive, and has learned to cherish each day. He has made his presence felt on the field and embodies the ideals that the team looks for in its players.
In two short years, the NFC West has gone from the worst division in the NFL to one of the best. All the teams have raced out to a hot start this season, and if the 49ers hope to win the division they will have to be at the top of their game. With the 49ers and Cardinals facing each other next Monday, San Francisco will either have control of the division or be in for a fight.
The 49ers will be rooting for the Vikings and Packers this weekend to help San Francisco stay alone at the top of the NFC West. The 49ers have played both teams this year and will find themselves rooting for them this week. With San Francisco looking to pad their division lead, and with tough games on their horizon the Cardinals and Rams need to win Sunday to keep up.
After another impressive performance for the 49ers, Frank Gore is slowly becoming on the best all around backs to ever grace the 49ers uniform. The ultimate goal has eluded him, but if the team can get him the ball early and often, they will be in a position to compete for a Super Bowl.
Jim Harbaugh's decision late in the 4th quarter of a 13-6 victory over the Seattle Seahawks Thursday caused his team to fall short of covering the betting spread, potentially shifting the payout of hundreds of millions of gambling dollars, according to a report from ESPN.
The former coach said those traits were enough to secure a narrow victory over the Seahawks, but won't be enough against other top teams.
The Thursday Night Game featured two of the NFC West's top teams, with the San Francisco 49ers earning the win. It should be no surprise that the man leading the way was Frank Gore, helped by another stellar performance by the 49ers defense.
Alex Smith threw a 12-yard touchdown pass to Delanie Walker late in the third quarter and San Francisco held off the Seattle Seahawks 13-6 on Thursday night as the 49ers won their long-awaited division opener.
Minnesota's Taj Bradley held the Giants to a run on three hits in six innings and the Twins knocked off San Francisco 3-2 on Tuesday night.
A football player at the College of San Mateo was killed and two others were injured in a solo-vehicle crash on Highway 101 in San Jose over the weekend, officials said.
The Golden State Valkyries are streaking into the WNBA playoffs and are looking to keep alive their chance to claim the No. 1 seed as they face the Portland Fire on Tuesday evening.
A high school on California's Central Coast has abruptly canceled the remainder of the 2026 football season as officials launch an investigation into the program.
Drew Gilbert homered and hit a two-run single, leading the San Francisco Giants past the Minnesota Twins 5-2 to snap a three-game losing streak.
Longtime San Francisco Giants broadcaster Duane Kuiper announced that he has been diagnosed with throat cancer and is undergoing treatment.
Christian McCaffrey became the fourth-fastest player in the Super Bowl era with 100 career touchdowns, Brock Purdy played a near-perfect game and the San Francisco 49ers overwhelmed the Miami Dolphins 35-13.
Kiké Hernández had a go-ahead RBI double in the seventh inning, Emmet Sheehan did not give up a run in 5 1/3 innings, and the Los Angeles Dodgers beat the San Francisco Giants 3-1 to complete a three-game sweep.
The bills are aimed at continuing current preparations, supporting key public safety partnerships and helping student athletes who will be competing in the Games.
Data centers are moving into the spotlight across the Bay Area, as cities try to figure out what they need to know before approving projects.
California voters who rely on mail-in ballots could face a greater risk of having their votes rejected if they wait until Election Day to return them, according to a new study examining recent changes to U.S. Postal Service operations.
With AI at the tips of her freshly manicured fingertips, Valerie Chapman is on a mission to course correct a societal construct as society steps into the future.
Suisun City has reopened all public access to City Hall after a cybersecurity incident last month forced city officials to close in-person services.
A longtime fixture on Fisherman's Wharf in San Francisco, Ripley's Believe it or Not! announced that the museum would close before the end of the year.
A longtime fixture on Fisherman's Wharf in San Francisco, Ripley's Believe it or Not! announced that the museum would close before the end of the year.
A football player at the College of San Mateo was killed and two others were injured in a solo-vehicle crash on Highway 101 in San Jose over the weekend, officials said.
A man accused in a drive-by mass shooting in San Francisco's Mission District in 2023 pleaded guilty on Monday to charges and was sentenced to a lengthy prison term.
A bill supported by San Francisco lawmakers that toughens penalties for drivers participating in sideshows across California has been signed into law by Gov. Gavin Newsom.
A mother gave birth to a baby girl while stuck in traffic in San Francisco's Golden Gate Park over the weekend, officials said.
Data centers are moving into the spotlight across the Bay Area, as cities try to figure out what they need to know before approving projects.
The State of California is finalizing a new set of regulations for hardening homes against wildfire. But the city of Berkeley has already created rules that exceed what the state is proposing.
Whether you call it the leaf blower effect or something similar, Harrison encampment residents both current and former believe the city's sweep has done just that.
A species of highly invasive mussel have been found at Alameda County's Lake Del Valle and it prompting authorities to issue a quarantine on boats that launch at the lake.
Last week, Gov. Newsom announced that he was cutting through the red tape to help Berkeley get a long-envisioned ferry terminal.
A San Jose man has been arrested on suspicion of murder after two people were found dead in two separate locations over the weekend, police said.
A high school on California's Central Coast has abruptly canceled the remainder of the 2026 football season as officials launch an investigation into the program.
Former Santa Clara County undersheriff Rick Sung was convicted in connection with a bribery scandal that led to the resignation of the former sheriff, according to prosecutors.
In a proactive effort to prevent a major wildfire from devastating Big Basin Redwoods State Park, a dedicated group of advocates is taking decisive action.
Firefighters on California's Central Coast battled a fire that broke out Friday at the same power plant where a massive lithium battery fire took place last year.
A football player at the College of San Mateo was killed and two others were injured in a solo-vehicle crash on Highway 101 in San Jose over the weekend, officials said.
In less than two weeks, cyclists will be able to enjoy a new paved path to head down to Sausalito and the North Bay.
Forward progress of a grass fire in Marin County has been stopped at more than 300 acres, crews said.
More than seven years after a deadly drive-by shooting in Fairfield, two reputed gang members have been found guilty, prosecutors said Friday.
A man who was found dead at the base of a cliff in the Marin Headlands this week was identified as a resident of Placer County, authorities said on Friday.
Minnesota's Taj Bradley held the Giants to a run on three hits in six innings and the Twins knocked off San Francisco 3-2 on Tuesday night.
A football player at the College of San Mateo was killed and two others were injured in a solo-vehicle crash on Highway 101 in San Jose over the weekend, officials said.
The Golden State Valkyries are streaking into the WNBA playoffs and are looking to keep alive their chance to claim the No. 1 seed as they face the Portland Fire on Tuesday evening.
A high school on California's Central Coast has abruptly canceled the remainder of the 2026 football season as officials launch an investigation into the program.
Drew Gilbert homered and hit a two-run single, leading the San Francisco Giants past the Minnesota Twins 5-2 to snap a three-game losing streak.
A San Jose man has been arrested on suspicion of murder after two people were found dead in two separate locations over the weekend, police said.
A man accused in a drive-by mass shooting in San Francisco's Mission District in 2023 pleaded guilty on Monday to charges and was sentenced to a lengthy prison term.
Former Santa Clara County undersheriff Rick Sung was convicted in connection with a bribery scandal that led to the resignation of the former sheriff, according to prosecutors.
A bill supported by San Francisco lawmakers that toughens penalties for drivers participating in sideshows across California has been signed into law by Gov. Gavin Newsom.
Deputies say Derek Spencer fired at tactical teams before he was shot and killed early Monday.
Data centers are moving into the spotlight across the Bay Area, as cities try to figure out what they need to know before approving projects.
With AI at the tips of her freshly manicured fingertips, Valerie Chapman is on a mission to course correct a societal construct as society steps into the future.
The claims window is open until Dec. 21, 2026. To file a claim, iPhone users must enter basic personal info and their iPhone's serial number.
California placed new restrictions on data centers, giving local communities more control over the electricity, land and water usage by the facilities.
"Most of society is still not aware of how quickly it's moving," Gates said of the latest advances in artificial intelligence.
The CDPH said an unvaccinated passenger who later was hospitalized with measles traveled around the country by train and bus, eventually moving through at least six California counties before heading to Denver, Colorado.
Officials in the East Bay city of Berkeley have issued a warning to residents and doctors amid a rising number of bats that have tested positive for rabies.
Patients taking the first-of-a-kind pill, called daraxonrasib, lived for a median of 13.2 months compared with 6.7 months for chemotherapy recipients, studies showed.
Moderna and Merck announced study results that reflect a "landmark moment" in treatment for one of the deadliest forms of skin cancer.
Multiple unpermitted street food vendors in Fairfield were cited for violations last week after inspections found them selling food unsafe for public consumption, authorities said.
California voters who rely on mail-in ballots could face a greater risk of having their votes rejected if they wait until Election Day to return them, according to a new study examining recent changes to U.S. Postal Service operations.
Justice Elena Kagan declined a request from a surrogate to intervene in a custody dispute with a California couple.
California Republican legislators are demanding an investigation into payments by state's high-speed rail project to consultants that a state watchdog last week called "wasteful and unallowable."
The city filed a lawsuit against President Donald Trump's social media company over the Truth API feed that provides wealthy subscribers early access to the president's posts.
The U.S., Denmark and Greenland signed a new security agreement bolstering the United States' military and security presence on the island.
California Attorney General Rob Bonta has joined a coalition of 19 attorneys general in supporting a federal lawsuit challenging Idaho's law that bars transgender students from using school restrooms and other sex-separated facilities that align with their gender identity.
Berlin police did not identify the suspect, who is still at large, by name but said that he was already known to police and is from Berlin.
LGBTQ+ communities have significantly higher rates of unemployment than the general population. Kelsi Thorud reports on how the City of Oakland is empowering LGBTQ+ job seekers during Pride Month.
The fallout over the opposition by a handful of San Francisco Giants players against the team's Pride Night celebrations has prompted an investigation of Major League Baseball by the Trump administration.
Major League Baseball has warned players about writing on their uniforms after San Francisco starter Landen Roupp and two other pitchers added Bible verses to their Pride Night caps on Friday night.
A longtime fixture on Fisherman's Wharf in San Francisco, Ripley's Believe it or Not! announced that the museum would close before the end of the year.
An autopsy by the Greenville County Coroner's Office determined Hayden Panettiere's death was due to an accidental overdose of several drugs, including fentanyl.
California established Sept. 25, 9-2-5, as Dolly Parton Day in honor of the beloved artist and as a nod to her 1980 iconic song "9 To 5".
The San Francisco Lowrider Parade returned to the Mission District Saturday, alongside a 45th anniversary art exhibit.
Orchestra musicians with the San Francisco Opera have ended a nearly weeklong strike, after reaching a tentative agreement.
Ever since the COVID-19 pandemic, the Oakland Unified School District has seen an alarming spike in the number of unhoused students in the school system who deal with a host of challenges far beyond what most children face.
Meteorologist and CBS News Bay Area's resident pilot Lt. Jessica Burch got a treat during Fleet Week, taking to the skies with one of the Blue Angels.
A Bay Area man discovered his devastating loss left him with a new opportunity to rethink how he lives -- follow his journey in virtual reality, 360-degree video.
A groundbreaking medical study involving the UCSF Medical Center has shown some colorectal cancer patients can safely skip radiation treatment and enjoy a potentially higher quality of life.
Every day, San Francisco bar pilot Captain Zach Kellerman goes through what might just be the world's most dangerous commute.
Kevin Ko reports.
Drew Andre reports.
Communities around the country are deciding what to do about the proliferation of data centers, and on Tuesday it was Oakland's turn to decide whether to pause a key part of the AI boom. Brad Hamilton reports.
Izabela de Vera Giron, who has alopecia areata totalis, an autoimmune disease that causes complete loss of her hair, found something more powerful than the teasing she has often gotten - her voice. Len Ramirez reports.
Some were surprised by the amount of support Donald Trump got from the Latino community in 2024, but now that may be shifting. And it's probably no surprise it's because of the economy. John Ramos reports.
In 2025, KPIX is moving to a new community service award: the CBS News Bay Area Icon Award. Submit nominations for an outstanding community hero at kpix.com/icon.
It's the most wonderful time of the year for a South Bay woman who has played Mrs. Claus for more than 40 years for the children of North San Jose's Alviso District.
For residents of the Oakland Hills, the prospect of another wildfire always remains a concern. This week's Jefferson Awards winner has made it his mission to make the hills and other high-risk areas safer.
In East Palo Alto -- where state education numbers show more than nine in ten public school students are low income and more than half are English learners -- many are finding hope and connection at the Boys & Girls Clubs of the Peninsula.
This week's Jefferson Award winner is Army veteran who continues to live a life of service into his 80s, by feeding hundreds of San Francisco families a week.
A Bay Area man who overcame tremendous obstacles to excel in school has made it his mission to gear up other students for success in the classroom and in life.
For Students Rising Above scholar Josh Collins it took moving across the country to realize the value of his Bay Area family.
Samir Hooker had to grow up fast after his stepfather was shot dead 12 years ago. Now he is watching over his mom and sister while attending UC Berkeley.
It's hard enough to graduate from one of the most prestigious schools in the country when you're the first in your family to go to college. Imagine doing that while you're also trying to protect your parents from being deported?
Some students who are the first in their families to go to college face the challenge of balancing a rigorous academic load while still working to help support their family back home.
