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The San Francisco 49ers were embarrassed for the second week in a row, this time at home in a 27-7 loss to the Indianapolis Colts. "It looked like the fifth and sixth quarter of the Seattle game (last week)," John Madden told the KCBS Radio morning crew.
The defense fought hard, but in the end could not hold up. With no help from the offensive side of the ball, the defense was fighting a losing battle, and the result was another resounding loss. This time though, its to a team, that San Francisco figured to beat. While there is reason to be concerned, the 49ers will be alright, and still on track for their 2013 goals.
San Francisco 49ers linebacker Aldon Smith will take an "indefinite" leave following his arrest on Friday on suspicion of driving under the influence of alcohol and possession of marijuana, team officials said Sunday.
Andrew Luck threw for 164 yards and ran for a 6-yard touchdown while facing college coach Jim Harbaugh for the first time, as the Indianapolis Colts beat the 49ers on Sunday.
Emotions aside for players and coaches with both the San Francisco 49ers and Indianapolis Colts, here are five things to watch for Sunday when the two teams face off for the first time since 2010 on Sunday at Candlestick Park at 1:15 p.m. on KPIX 5.
Jim Harbaugh spent the better part of two seasons building gameplans tailored to the strengths of Andrew Luck, who more often than not executed his coach's schemes.
San Jose police say San Francisco 49ers linebacker Aldon Smith has been arrested on suspicion of driving under the influence.
San Francisco will be breaking in a new starting nose tackle against the Colts, has yet to gain clearance for starting rookie safety Eric Reid and has three other key starters who either missed practice or were limited this week with injuries.
Family pride, bragging rights, even control of the dinner-table conversation. It's all part of a high-stakes poker game in the first-ever head-to-head matchup between 49ers tight end Vernon Davis and Colts cornerback Vontae Davis.
The scoreboard is not the only place where the 49ers were beat up this past weekend. After a relatively injury free start to the season, there are several players who now fill up the injury report, but the news is not all bad. Their opponent has two very significant injuries, and this game will not be nearly as physical as the war that was the game against Seattle.
Coming off an embarrassing loss to the Seattle Seahawks Sunday night, the San Francisco 49ers face the Indianapolis Colts at Candlestick Sunday afternoon. "You don't have a lot of time to pout," John Madden told the KCBS Radio morning crew.
The San Francisco 49ers play the Indianapolis Colts at Candlestick Sunday in a game featuring a former Stanford coach, Jim Harbaugh, and his star college quarterback, Andrew Luck. "Andrew Luck and that Colt offense, they can play," John Madden told the KCBS Radio morning crew.
Trent Richardson will now get a crash course on the Colts' offense and is likely to play this weekend at San Francisco.
No matter that opponents are stacking extra defenders next to the line of scrimmage. The San Francisco 49ers are determined to run the football successfully, a key element of their offense that has been missing through the first two weeks of the season.
In two games, the Seahawks' swarming defense has surrendered only 10 points, shutting down Carolina and San Francisco. They've made Cam Newton and Colin Kaepernick look confused, created game-changing turnovers and shown just how much fun it is making the game miserable for others.
Donovan Mitchell had 25 points and six rebounds, Max Strus' 3-pointer with 54 seconds left helped seal it as he scored 24, and the Cleveland Cavaliers beat the Golden State Warriors 118-111.
San Francisco rookie catcher Daniel Susac went 3 for 3 with a walk in his first four big league at-bats and the Giants rolled over the New York Mets 7-2.
Zack Ostapchuk scored his first goal in nearly three months and the San Jose Sharks beat the Toronto Maple Leafs 4-1 on Thursday night for their fourth straight victory.
Macklin Celebrini scored with less than two minutes to play to tie the game then assisted on Alexander Wennberg's winning goal with 31 seconds left to complete a four-point game as the San Jose Sharks beat the Anaheim Ducks 4-3.
Willy Adames had four hits, including a leadoff homer, and San Francisco ace Logan Webb finished strong in the Giants' 9-3 victory over the San Diego Padres.
Adam Gaudette scored with 21 seconds left, Alexander Wennberg and Macklin Celebrini each had two goals and an assist, and the San Jose Sharks beat St. Louis 5-4 to snap the Blues' three-game winning streak.
Harrison Bader connected against Walker Buehler for San Francisco's first home run this season and the Giants held off the San Diego Padres 3-2 to give rookie manager Tony Vitello his first victory.
The Super Bowl will return to Las Vegas in 2029 for the second time after NFL owners voted Monday to award the nation's gambling and entertainment capital the big game.
The Milwaukee Brewers have acquired outfielder Luis Matos from the San Francisco Giants for cash.
Walk into The Sewing Room in the heart of Alameda on any given evening, and you would find a place bursting at the seams.
A second teenage suspect in the killing of a 17-year-old boy in the San Francisco Bay Area was arrested in San Bernardino County, police said on Friday.
A fire at a San Francisco International Airport cargo area on Friday afternoon sent billowing smoke over the airport as well as lanes of U.S. Highway 101 and adjacent BART and AirTrain tracks.
A man who posed as a ride-hailing driver outside San Francisco nightclubs and preyed on women who mistook him for their driver was convicted of multiple rapes, the district attorney announced Friday.
Officials from 23 states and the District of Columbia filed a lawsuit seeking to block President Trump's executive order that aims to restrict mail voting.
A man who posed as a ride-hailing driver outside San Francisco nightclubs and preyed on women who mistook him for their driver was convicted of multiple rapes, the district attorney announced Friday.
San Francisco's Glide Foundation has inaugurated "The Shop," a new program that pairs free haircuts with access to health services and community support inspired by the historic role of barbershops in Black communities.
A magnitude 4.6 earthquake struck in Santa Cruz County early Thursday morning and was felt by residents throughout the Bay Area.
Four candidates vying for the 11th Congressional seat made their best pitch to voters during a debate at Golden Gate Park.
A driver led San Francisco police onto the Bay Bridge during a car chase Wednesday evening and caused a temporary closure of multiple eastbound lanes, just west of Treasure Island, police said.
Walk into The Sewing Room in the heart of Alameda on any given evening, and you would find a place bursting at the seams.
A home-based food movement has been heating up in California, with home cooks turning their beloved family recipes into small businesses.
A dead bat found at a Fremont home earlier this week has tested positive for the deadly rabies virus, according to authorities.
Five months after being mistakenly released from the Contra Costa County Jail, a homicide suspect has been arrested, authorities said.
Police in Oakland on Wednesday released data that showed declines in crime during the first three months of 2026.
The Computer History Museum is more than a walk through the past; it is a reflection of how rapidly technology continues to shape everyday life.
A magnitude 4.6 earthquake struck in Santa Cruz County early Thursday morning and was felt by residents throughout the Bay Area.
A teenager has died, and another teen has been arrested on a homicide charge following a fight near Milpitas High School on Tuesday afternoon.
Police executing a search warrant in a Salinas home found a cooler filled with methamphetamine near a child's bed, among other drug and gun evidence, police said Wednesday.
A San Jose man is facing decades in federal prison after he pled guilty to robbing and attacking a mail carrier for the U.S. Postal Service, prosecutors said.
A 12-year-old Santa Rosa girl missing since late Thursday evening was found safe, police said Friday afternoon.
A Sonoma County man has been arrested on multiple weapons charges and a hate crime charge, after he allegedly pointed a gun and made racist remarks from the roof of his home.
An American Canyon man was charged on Wednesday with manslaughter and driving under the influence following a weekend crash in Napa County that left three people dead and four others severely injured, prosecutors said.
A suspect was positively linked to the cold case murder of Marjorie Rudolph, a San Rafael woman killed inside her home in 1966, police announced Tuesday.
A Rohnert Park man was arrested after being accused of sexually assaulting a child under 14 years old, authorities said.
Donovan Mitchell had 25 points and six rebounds, Max Strus' 3-pointer with 54 seconds left helped seal it as he scored 24, and the Cleveland Cavaliers beat the Golden State Warriors 118-111.
San Francisco rookie catcher Daniel Susac went 3 for 3 with a walk in his first four big league at-bats and the Giants rolled over the New York Mets 7-2.
Zack Ostapchuk scored his first goal in nearly three months and the San Jose Sharks beat the Toronto Maple Leafs 4-1 on Thursday night for their fourth straight victory.
Macklin Celebrini scored with less than two minutes to play to tie the game then assisted on Alexander Wennberg's winning goal with 31 seconds left to complete a four-point game as the San Jose Sharks beat the Anaheim Ducks 4-3.
Willy Adames had four hits, including a leadoff homer, and San Francisco ace Logan Webb finished strong in the Giants' 9-3 victory over the San Diego Padres.
A second teenage suspect in the killing of a 17-year-old boy in the San Francisco Bay Area was arrested in San Bernardino County, police said on Friday.
A man who posed as a ride-hailing driver outside San Francisco nightclubs and preyed on women who mistook him for their driver was convicted of multiple rapes, the district attorney announced Friday.
An Oakland man has been arrested nearly three months after an attempted armed robbery in Suisun City, police said on Thursday.
Five months after being mistakenly released from the Contra Costa County Jail, a homicide suspect has been arrested, authorities said.
Police in Oakland on Wednesday released data that showed declines in crime during the first three months of 2026.
The Computer History Museum is more than a walk through the past; it is a reflection of how rapidly technology continues to shape everyday life.
NASA said they had more than 2,600 submissions from around the world for the zero-gravity indicator mascot. Officials added that the Artemis II crew was inspired by 8-year-old Lucas Ye's creativity.
Officials in Foster City said Friday that they are making progress in restoring services, more than a week after a cybersecurity breach brought the city's network down and led to a state of emergency.
Experts say the rulings could expose tech companies to more litigation and pressure them to make changes to their apps.
The verdict, which caps a weeks-long trial in Los Angeles, could set a legal precedent for similar allegations brought against social media companies.
A dead bat found at a Fremont home earlier this week has tested positive for the deadly rabies virus, according to authorities.
An East Bay woman is using the sport of pickleball to help find a cure for Parkinson's disease.
An unlicensed cosmetologist from Florida has been found guilty in a California court for providing an injection that killed a model who was known as a Kim Kardashian lookalike, prosecutors said.
The early-season heat wave gripping the Bay Area also means the allergy season is already kicking into high gear.
He advises people to lie down, extend their arms, and hold the phones above their heads, or people should hold their phone at eye level, rather than looking down.
Officials from 23 states and the District of Columbia filed a lawsuit seeking to block President Trump's executive order that aims to restrict mail voting.
The search for the second crew member, a weapons system officer, is continuing, two U.S. officials said.
A key senator is demanding the TSA reverse its decision to let travelers keep their shoes on while passing through airport screening, a controversial policy at the center of a classified security warning.
For years, California leaders accused oil companies of price gouging at the pump, but a state investigation found no evidence of that. Instead, a CBS News California investigation found what's really driving the highest gas prices in the U.S.
One of the sources said Hegseth wants someone in the role who will implement President Trump and Hegseth's vision for the Army.
Transgender women athletes are now excluded from women's events at the Olympics after the IOC agreed to a new eligibility policy on Thursday.
The Trump administration has given San Jose State University 10 days to change its policy on transgender athletes or face legal action and possibly lose federal funding.
A man has been arrested and accused of a hate crime after a San Francisco church was vandalized over the weekend, police said.
A Yosemite park ranger was fired last year after helping to display a transgender pride flag from El Capitan.
After more than two years of renovations, the historic Castro Theatre is back open for business.
City leadership recently passed legislation that they say will help established event activators plan and execute at a much faster pace.
The price hike raises the cost of the standard plan with ads by $1 per month and the cost of the standard and premium plans by $2.
An unlicensed cosmetologist from Florida has been found guilty in a California court for providing an injection that killed a model who was known as a Kim Kardashian lookalike, prosecutors said.
Through his social media channel, "Festus Feasts," NBA champion Festus Ezeli is on a mission to give a boost to local restaurants throughout the region.
CBS News announced Friday that CBS News Radio will be shutting down this spring after nearly 100 years of broadcasting, citing "challenging economic realities."
Ever since the COVID-19 pandemic, the Oakland Unified School District has seen an alarming spike in the number of unhoused students in the school system who deal with a host of challenges far beyond what most children face.
Meteorologist and CBS News Bay Area's resident pilot Lt. Jessica Burch got a treat during Fleet Week, taking to the skies with one of the Blue Angels.
A Bay Area man discovered his devastating loss left him with a new opportunity to rethink how he lives -- follow his journey in virtual reality, 360-degree video.
A groundbreaking medical study involving the UCSF Medical Center has shown some colorectal cancer patients can safely skip radiation treatment and enjoy a potentially higher quality of life.
Every day, San Francisco bar pilot Captain Zach Kellerman goes through what might just be the world's most dangerous commute.
For a growing number of people more concerned about cost, waste, and learning practical skills, sewing was suddenly back in style. Itay Hod reports.
While some areas of San Francisco have seen a large drop in the number of tents belonging to homeless persons, in the South of Market area has seen a surge. Kenny Choi reports.
It's a dilemma many Bay Area neighborhoods are facing, balancing the need to build housing against wildfire risk. Cupertino residents say a major townhome project just approved by the city could put their entire neighborhood in danger. Kevin Ko reports.
The Port of Oakland is looking at ways to turn around the slumping passenger volume at Oakland San Francisco Bay Airport, a problem that has persisted since the pandemic. Brad Hamilton reports.
Meteorologist Paul Heggen says after the weekend warmup, cooler and cloudier days are ahead.
In 2025, KPIX is moving to a new community service award: the CBS News Bay Area Icon Award. Submit nominations for an outstanding community hero at kpix.com/icon.
It's the most wonderful time of the year for a South Bay woman who has played Mrs. Claus for more than 40 years for the children of North San Jose's Alviso District.
For residents of the Oakland Hills, the prospect of another wildfire always remains a concern. This week's Jefferson Awards winner has made it his mission to make the hills and other high-risk areas safer.
In East Palo Alto -- where state education numbers show more than nine in ten public school students are low income and more than half are English learners -- many are finding hope and connection at the Boys & Girls Clubs of the Peninsula.
This week's Jefferson Award winner is Army veteran who continues to live a life of service into his 80s, by feeding hundreds of San Francisco families a week.
A Bay Area man who overcame tremendous obstacles to excel in school has made it his mission to gear up other students for success in the classroom and in life.
For Students Rising Above scholar Josh Collins it took moving across the country to realize the value of his Bay Area family.
Samir Hooker had to grow up fast after his stepfather was shot dead 12 years ago. Now he is watching over his mom and sister while attending UC Berkeley.
It's hard enough to graduate from one of the most prestigious schools in the country when you're the first in your family to go to college. Imagine doing that while you're also trying to protect your parents from being deported?
Some students who are the first in their families to go to college face the challenge of balancing a rigorous academic load while still working to help support their family back home.
