The Dow Jones Industrial Average was down 12 points at 12,750, with 18 of its 30 components opening higher.
General Motors Corp. posted the biggest gains among blue chips, rising 1.6%. The automaker's gains followed news of a surprise profit at Ford Motor Co. .
The broad S&P 500 index rose 1.67 points, or 0.1%, to 1,381, while the Nasdaq Composite lost 1.4 points, or 0.1%, to 2,403, weighed down by the cloudy outlook from Amazon.com whose shares lost 3%.
The market also came under pressure from the energy sector, which fell 2%, and the materials sector, which lost 1%.
A stronger dollar brought down the price of dollar-denominated commodities, such as crude oil and gold, weighing on the shares of oil producers and metals miners. Oil futures fell $1.31 to $117 a barrel and gold futures broke back under the $900 an ounce mark.
Dollar strength was especially pronounced against the euro, which fell sharply after a closely watched German business climate poll fell more than economists had forecast.
A surprise drop in U.S. jobless claims further boosted the dollar. First-time claims for state unemployment benefits fell to its lowest level in two months in the latest week, the Labor Department reported Thursday. The number of initial claims in the week ending April 19 fell 33,000 to 342,000.
Meanwhile, orders for U.S.-built durable goods slipped 0.3% in March, the third decline in a row, the Commerce Department estimated. But the decline was as expected by economists following an upwardly revised 0.9% decline in February.
New home sales may have slipped 2% from February levels, according to economists polled by MarketWatch. That data is due out at 10 a.m. Eastern.
The interest rate debate may be back in focus as The Wall Street Journal said the Federal Reserve may consider a pause in rate cuts after making a quarter-point reduction next week.
Apple gained 0.15%. While the Macintosh and iPhone maker recorded 36% profit growth and 43% sales growth during its fiscal second quarter, its current quarter outlook was on the cautious side.
"While the conservative EPS forecast is not untypical of this management team, we are concerned that slowing first-quarter cash flow momentum could flow through into second-quarter earnings realizations," said analysts from Credit Suisse.
Ford Motor Co. returned to profitability, earning $100 million during the first quarter, and said revenue outside Jaguar Land Rover and Aston Martin climbed. Ford shares climbed 5.5% in pre-open trade.
Whirlpool dropped 8% after it cut its earnings outlook for the year.
Starbucks dropped 12% as the coffee retailer warned second-quarter and annual profit will be hurt by decreased traffic at U.S. stores and a weakening of the U.S. consumer environment.
Amazon fell 4% as the online retailer's flat margins offset a 30% profit rise.
"Like last quarter, revenue results and outlook are outstanding, given the recessionary environment," Mark Mahaney of Citigroup wrote in a note to clients. "Also like last quarter, the margin outlook is disappointing."
After the closing bell, Microsoft will report results.
One major M&A transaction had Wendy's and Triarc coming together in a $2.3 billion deal.
Overseas, Shanghai stocks surged 9% on the government's move to repeal a stamp duty tax. But other international markets weren't as strong, with the FTSE 100 down 1.7% in London.
U.S. stocks ended higher on Wednesday, with better-than-forecast results from Boeing helping steer stocks up in a choppy session. The Dow industrials finished nearly 43 points higher, the S&P 500 rose lmost 4 points and the Nasdaq Composite rose 28 points.
By Nick Godt