John Stamos to replace Charlie Sheen on "Two and a Half Men"?

(CBS) Could Uncle Jesse be filling in for Charlie Harper?

That's what the rumor mill is saying, at least - that former "Full House" actor John Stamos may replace Charlie Sheen on "Two and a Half Men."

Pictures: Charlie Sheen
Pictures: Sheen's ups and downs

Stamos shot down the speculation on his Twitter account, writing, "Contrary to the rumors, i am not replacing charlie sheen on two and half men," he Tweeted, before throwing in a little joke: "However, martin sheen has asked me to be his son."

He also set the record straight on "Extra," saying, "I don't think so. I hope Charlie does okay."

Sources also told TMZ.com that "the off-handed comment about Stamos replacing Sheen was a joke."

But rumor or not, the idea didn't sit well with Sheen, who called the thought of Stamos replacing him "a tragic joke."

He told TMZ, "If they do that then they deserve their failures and the follies."