The Louisiana State Police says one person was killed in an early Friday accident in Iberville Parish in southern Louisiana involving three 18-wheelers and a pickup truck.
In Mississippi, the Highway Patrol said a man and a woman died in separate wrecks Thursday on ice patches on Interstate 10. Another woman was killed when her SUV slid on an icy bridge and hit an oncoming log truck.
Dozens of schools, businesses and government offices in north Alabama were opening late.
State government offices were closed in 55 of Louisiana's 64 parishes
Forecasters say temperatures should rise above freezing later in the day.