Released by Warner Bros., "The Final Destination" raised its 11-day total to $50.6 million.
Quentin Tarantino's World War II epic "Inglourious Basterds" ran a close second with $15 million from Friday to Monday. The Weinstein Co. tale lifted its total to $95.2 million in its third weekend.
Debuting at No. 3 with $13.9 million was 20th Century Fox's romantic comedy "All About Steve," starring Sandra Bullock on a cross-country trek pursuing the man of her dreams.
Among the weekend's other new releases was Lionsgate's thriller "Gamer," which pulled in $11.2 million to finish at No. 4. "Gamer" stars Gerard Butler in a tale about real humans controlled by players in deadly games.
Opening at No. 10 with $5.3 million was Miramax's comedy "Extract," starring Jason Bateman as a businessman whose personal life heats up just as he's trying to sell his flavor-extract company to General Mills.
The Labor Day weekend is traditionally a slow one at theaters, with audiences preoccupied by outdoor activities and a new school year. But with Hollywood fresh off a summer revenue record of $4.25 billion, theaters did solid business over the holiday, with receipts for the top-12 movies at $102.6 million, up 10.5 percent from Labor Day weekend last year, according to box-office tracker Hollywood.com.
"It's been a huge summer," said Bert Livingston, 20th Century Fox distribution executive. "Especially when the economy has been the way it is, our business is thriving, because people want to escape and go and lose themselves for a couple of hours."
For the year, Hollywood revenues are running at a record pace of $7.4 billion, 7.8 percent ahead of 2008 ticket sales. Factoring in higher ticket prices, admissions for 2009 are up 4 percent compared to last year's, according to Hollywood.com.
"We couldn't be in a better position heading into the fall," said Paul Dergarabedian, Hollywood.com box-office analyst. "We've got momentum with us."
Estimated ticket sales for Friday through Monday at U.S. and Canadian theaters, according to Hollywood.com.
1. "The Final Destination," $15.4 million.
2. "Inglourious Basterds," $15 million.
3. "All About Steve," $13.9 million.
4. "Gamer," $11.2 million.
5. "District 9," $9 million.
6. "Halloween II," $7.1 million.
7. "Julie & Julia," $7 million.
8. "G.I. Joe: The Rise of Cobra," $6.7 million.
9. "The Time Traveler's Wife," $5.5 million.
10. "Extract," $5.3 million.