BEARS 26, LIONS 24
DETROIT Jay Cutler threw for 257 yards and a touchdown and helped seal the game with a late scramble.
Chicago (10-6) needed a Minnesota loss to Green Bay to reach the postseason.
The Lions (4-12) lost their last eight games and turned the ball over four times in the finale. Calvin Johnson fell short in his attempt to become the first player with 2,000 yards receiving in a season.
Cutler's 19-yard run on third down helped Chicago run out the clock late in the fourth quarter.
GIANTS 42, EAGLES 7
EAST RUTHERFORD, N.J. There will be no Super Bowl repeat for the Giants. Not even a playoff berth despite Eli Manning's career-high five touchdown passes.
The Giants (9-7) playoff hopes ended minutes after routing the Eagles. Chicago's win over Detroit ended New York's long-shot playoff chances.
Eagles coach Andy Reid is out after 14 years at Philadelphia, three people familiar with the decision told The Associated Press. The official announcement could come Monday.
The loss means that it will be seven straight seasons that the Super Bowl champion has failed to win a playoff game the following year.
Philadelphia closed the season 4-12.
STEELERS 24, BROWNS 10
PITTSBURGH Ben Roethlisberger threw three short touchdown passes, and Pittsburgh avoided its first losing season in nearly a decade.
Antonio Brown, Leonard Pope and Plaxico Burress scored for the Steelers (8-8). Pittsburgh's top-ranked defense forced four turnovers as the Steelers won for just the second time in the last six weeks, a slide that knocked them out of the playoffs for the first time since 2009.
Cleveland's third-string quarterback, Thaddeus Lewis, passed for 204 yards with a touchdown and an interception in his first NFL start. But the Browns (5-11) dropped their third straight in what is likely coach Pat Shurmur's final game.
BILLS 28, JETS 9
ORCHARD PARK, N.Y. C.J. Spiller scored on a 66-yard catch and run in helping underachieving Buffalo, while Jets quarterback Mark Sanchez had two more turnovers.
Safety Bryan Scott also returned an interception 20 yards for a touchdown for the Bills (6-10), who snapped a three-game skid. Both AFC East rivals had already been eliminated from playoff contention.
The Bills finished last in the AFC East for a fifth straight season amid speculation about coach Chan Gailey's job security.
Sanchez may have started his final game for the Jets (6-10), who closed the season with three consecutive losses amid all sorts of turmoil.
TITANS 38, JAGUARS 20
NASHVILLE, Tenn. Tennessee became the first NFL team with two players scoring twice on returns in closing out the season with two wins in its final three games.
Darius Reynaud scored on two punt returns and rookie linebacker Zach Brown returned two interceptions for touchdowns.
The Titans finished 6-10 and await owner Bud Adams' decision on whether to keep coach Mike Munchak, who has two years left on his contract.
The Jaguars (2-14) wrapped up their worst season with their 12th loss in 13 games, and now owner Shad Khan has to decide on the futures of general manager Gene Smith and first-year coach Mike Mularkey.
PANTHERS 44, SAINTS 38
NEW ORLEANS Drew Brees made more NFL history, but so did the Saints' porous defense in a loss to Carolina.
DeAngelo Williams rushed for 210 yards, including touchdown runs of 54 and 12 yards, for Carolina (7-9), which closed the season with four straight wins. His 65-yard gain set up the first of three 1-yard scoring runs by Mike Tolbert.
Brees passed for 396 yards, giving him 5,177 this season. That makes him the first player to eclipse 5,000 yards three times. His four TD passes gave him 43 in 2012, and he's the first player with 40 TD passes in consecutive seasons.
The Saints (7-9) also gave up 530 yards, raising their season total to 7,042 to break the record of 6,793 allowed by the 1981 Baltimore Colts.
CHARGERS 24, RAIDERS 21
SAN DIEGO Micheal Spurlock returned the opening kickoff 99 yards for a touchdown on wet, gloomy day in what's expected to be Norv Turner's final game as Chargers coach.
Turner and general manager A.J. Smith are expected to be fired because the Chargers (7-9) missed the playoffs for the third straight season. The Raiders finished 4-12.
Spurlock became the first Chargers player to have a kickoff and punt return for touchdowns in consecutive weeks. He returned a punt 63 yards for a touchdown a week earlier in a victory against the New York Jets.