The Globe, on its Web site, reported that the Boston Newspaper Guild voted 366-179 to accept the deal that was hammered out after the union narrowly voted down a similar package last month.
The Guild represents editorial, advertising and business employees at the Globe.
The newspaper's parent, The New York Times Co., imposed a 23 percent wage cut after the union which represents about 700 editorial, advertising and business employees voted down a new contract that called for an 8.3 percent wage cut, unpaid furloughs, benefit cuts and the elimination of lifetime job guarantees for nearly 200 staffers.
The new contract cuts salaries by nearly 6 percent. It also includes unpaid furloughs, a pension freeze, a reduction in health care benefits and the elimination of lifetime job guarantees.
The Globe is projected to lose $85 million this year.
"We are very pleased that the members of the Boston Newspaper Guild ratified their agreement. With this vote, all of the Globe's major union contracts are now settled," Boston Globe spokesman Bob Powers said in a statement.
"We deeply appreciate the sacrifices that Guild members are making to help sustain The Boston Globe's mission of delivering high-quality journalism to the greater Boston community," he added.
The Times Co. said it needed $10 million in wage and benefit concessions from the Guild on top of $10 million in concessions it negotiated with six other unions.
The Guild filed a complaint with the National Labor Relations Board after management imposed the 23 percent wage cut, but a hearing before the NRLB has been postponed while talks continue.