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Ohtani (3-1) made his first start on the mound since April 24.
Los Angeles stranded 13 runners and went 0 for 9 with runners in scoring position.
The Los Angeles ace is dealing with biceps tendinitis.
Both teams staged rallies in the eighth and ninth innings, and Seattle overcame runs by the Angels in the 10th and 11th.
San Diego (12-22) ended a two-game losing streak.
Shohei Ohtani was lustfully booed by Seattle fans in his first game in the Pacific Northwest.
Pujols became the second Dominican player to reach 3,000 hits.
Mexico had waited since 1999 to host a regular-season major league game, and it got a historic one.
Who is the best driver in the history of golf? CBS Sports golf analysts weigh in.
Justify is the favorite for Saturday's race, but there are a few other horses to consider as well.
With NBA and NHL playoff series getting interesting and MLB teams rounding into form, SportsLine offers its top picks for the weekend.
Angels rookie right-hander Jaime Barria (2-1) took a no-hitter into the sixth inning.
The Dodgers scored four times in the eighth and handed Arizona its first two-game losing streak this year.
WWE insiders break down the WWE's upcoming Backlash pay-per-view, which brings together many of RAW and SmackDown's biggest stars.
Wilson was suspended three games by the league on Wednesday night after his hit on Pens forward Zach Aston-Reese broke Reese's jaw.
Months after a 13-year-old Rancho Cucamonga girl was left paralyzed from an injury sustained during a dance class, she's defying the odds and learning to walk again.
A federal judge temporarily blocked President Trump's ban CNN, MS NOW and Politico from the White House, but access has not yet been restored.
Lawrence Tanter, the longtime public address announcer known as the "Voice of the Lakers," has died at the age of 76.
A group of neighbors took down a burglary suspect after he forced his way into a woman's apartment in Sherman Oaks.
The Los Angeles Police Department is in pursuit of a robbery suspect through the San Fernando Valley.
Lawrence Tanter, the longtime public address announcer known as the "Voice of the Lakers," has died at the age of 76.
A group of neighbors took down a burglary suspect after he forced his way into a woman's apartment in Sherman Oaks.
The Los Angeles Police Department is in pursuit of a robbery suspect through the San Fernando Valley.
The city of Santa Monica is planning construction on the Pier Bridge, and promises to return the sign, refurbished with its historic character intact, when construction is complete, in late 2027.
A new poll shows Councilwoman Nithya Raman leading Mayor Karen Bass by double digits in the Los Angeles mayoral race.
The Irvine Police Department evacuated a shopping center after officers found a pipe bomb inside a car parked at a nearby gas station.
An Orange County family reunited with the Irvine police officers who saved their son's life after he was underwater and unconscious for nearly 10 minutes.
Wildlife experts say that a sea turtle has nested on a West Coast beach for the first time in recorded history after eggs were laid in both Seal Beach and Huntington Beach last week.
A second storm-battered oceanfront home in Capistrano Beach has been torn down, while eight houses in the private development on Beach Road are red-tagged and seven remain yellow-tagged.
Newport Beach's eroding shoreline is getting some help as city and county authorities approved the expedited transfer of sand from the Santa Ana River outlet in West Newport.
Months after a 13-year-old Rancho Cucamonga girl was left paralyzed from an injury sustained during a dance class, she's defying the odds and learning to walk again.
The San Bernardino Police Department said two victims and a gunman were hospitalized after a shooting Wednesday morning.
Cold case homicide detectives said that the woman's body was found 14 years after she was allegedly killed in the crawlspace of a Big Bear Lake home.
A man who jumped into action trying to save a pregnant woman escaping from an apartment fire in Riverside may lose his legs after his heroic efforts.
Hundreds of cats were seized from two units linked to a Southern California nonprofit rescue in an animal-hoarding case.
A Tennessee judge granted Dolly Parton's estate a temporary restraining order Wednesday against the late singer's nephew Bryan Seaver and his private security company.
Nolo is expected to become a hurricane sometime Thursday and could become a major hurricane by the weekend as it approaches Hawaii's Big Island.
Raising payroll taxes enough to stabilize Social Security could add thousands of dollars in annual costs, according to one analysis.
The ICE officer who shot a Venezuelan delivery driver was not wearing a body camera at the time of the shooting, sources familiar with the investigation told CBS News.
An autopsy by the Greenville County Coroner's Office determined Hayden Panettiere's death was due to an accidental overdose of several drugs, including fentanyl.
A federal judge temporarily blocked President Trump's ban CNN, MS NOW and Politico from the White House, but access has not yet been restored.
Gov. Gavin Newsom has vetoed legislation that would have changed how California determines financial eligibility for some immigrants receiving state-funded food assistance.
A new poll shows Councilwoman Nithya Raman leading Mayor Karen Bass by double digits in the Los Angeles mayoral race.
There have been eight suicide attempts across the USS Abraham Lincoln carrier strike group since the beginning of its grueling monthslong deployment last year, Acting Navy Secretary Hung Cao said.
California voters who rely on mail-in ballots could face a greater risk of having their votes rejected if they wait until Election Day to return them, according to a new study examining recent changes to U.S. Postal Service operations.
Homeowners getting their insurance through the California FAIR Plan will soon be paying even more, but industry observers say it may be a good sign for the state's insurance market.
Voters in California may soon decide on a ballot measure that seeks to help the state's middle class afford to buy a home, by establishing a $25 billion loan program that would provide down payment assistance.
Some Trader Joe's shoppers will get a payout after a lawsuit alleged that the retailer's customer receipts put shoppers at risk of ID theft.
California Attorney General Rob Bonta and local prosecutors urged parents to check their children's e-bikes, saying some of the vehicles may be motorcycles or mopeds capable of high speeds.
San Francisco officials said Tuesday that the city has filed a lawsuit against leading manufacturers of ultra-processed foods, accusing them of producing products linked to serious health issues and alleging that the companies knowingly made the foods addictive.
Los Angeles County Department of Public Health officials on Monday reported that the county has recorded 100 West Nile virus cases this year, marking the highest number in nearly a decade.
The CDPH said an unvaccinated passenger who later was hospitalized with measles traveled around the country by train and bus, eventually moving through at least six California counties before heading to Denver, Colorado.
Patients taking the first-of-a-kind pill, called daraxonrasib, lived for a median of 13.2 months compared with 6.7 months for chemotherapy recipients, studies showed.
Moderna and Merck announced study results that reflect a "landmark moment" in treatment for one of the deadliest forms of skin cancer.
The Social Security Administration is expanding its list of diseases and other health conditions that may qualify for accelerated approval of disability benefits.
California placed new restrictions on data centers, giving local communities more control over the electricity, land and water usage by the facilities.
About 43,000 people are expected to attend the annual AI and enterprise tech conference hosted by Salesforce which comes amid calls for a slowdown in AI developments.
Pest control company Terminix has agreed to pay $3.15 million to settle a lawsuit brought by 29 California counties alleging the company unlawfully disposed of pesticides and violated customer privacy laws.
As Californians prepare to celebrate Labor Day and the contributions of American workers, labor unions are raising alarms about what they see as a growing threat to the future of human work.
California regulators approved Waymo to expand its services in Los Angeles and the Bay Area, and to offer its autonomous ride-hailing service in Sacramento and San Diego in the future, the company said Friday.
Manny Machado homered and drove in three runs as the San Diego Padres beat the Los Angeles Dodgers 5-1 to take sole possession of the top spot in the National League wild-card standings.
Donovan Walton hit a three-run homer and rookie Henry Bolte had his first four-hit game to help the Athletics beat the Los Angeles Angels 7-3 on Wednesday night.
Shohei Ohtani returns to the Dodgers' lineup after missing two weeks with right biceps discomfort.
Carlos Cortes and Zack Gelof each hit a two-run homer in the eighth inning as the Athletics rallied for a 7-6 victory over the Los Angeles Angels.
Tommy Edman and Will Smith homered as the Los Angeles Dodgers scored five runs with two outs to beat the San Diego Padres 7-0 in a series opener between rivals with the two best records in the majors this month.
A Tennessee judge granted Dolly Parton's estate a temporary restraining order Wednesday against the late singer's nephew Bryan Seaver and his private security company.
An autopsy by the Greenville County Coroner's Office determined Hayden Panettiere's death was due to an accidental overdose of several drugs, including fentanyl.
Presley Gerber, the son of Cindy Crawford and Rande Gerber, has died at 27, a family spokesperson has confirmed.
California established Sept. 25, 9-2-5, as Dolly Parton Day in honor of the beloved artist and as a nod to her 1980 iconic song "9 To 5".
California's film industry rejoiced on Saturday as Gov. Gavin Newsom signed a bill that will create a post-production tax credit and hopefully keep the work in Hollywood.
Months after a 13-year-old Rancho Cucamonga girl was left paralyzed from an injury sustained during a dance class, she's defying the odds and learning to walk again. Lesley Marin reports.
Hunter Sowards takes a look at the potential impacts of Hurricane Polo on Southern California.
Hundreds of La Verne residents remained evacuated nearly 48 hours after an explosive lithium-ion battery fire erupted at the Metropolitan Water District facility. Brittney Ermon reports.
A hit-and-run driver killed a teen and hospitalized his younger sister in a crash along a South LA street. Laurie Perez reports.
A new poll shows Councilwoman Nithya Raman leading Mayor Karen Bass by double digits in the Los Angeles mayoral race. Tom Wait reports.
Some of golf's best are facing off at the U.S. Women's Open at the Riviera Country Club in the Pacific Palisades over the weekend. The event runs from June 2 to June 7.
Widely considered the greatest architect of his time, Frank Gehry helped shape Los Angeles' skyline.
A suspect was taken into custody after an attack on Pearl Street Mall in Boulder on June 1 in which there were 15 people and a dog who were victims. The suspect threw Molotov cocktails that burned some of the victims, who were part of a march for Israeli hostages.
A look back at the esteemed personalities who've left us this year, who'd touched us with their innovation, creativity and humanity.
The Franklin Fire in Malibu quickly grew overnight and threatened several homes. Evacuation orders were issued and Pepperdine University instructed students to shelter in place.
