The study, called Look AHEAD (Action for Health in Diabetes), included 5,145 people with type 2 diabetes.
The key finding: Losing a modest amount of weight — about 8 percent — reaped big health rewards, including better blood sugar control and less need for diabetes and blood pressure drugs.
"We're encouraged, based on our experience with Look AHEAD, that many overweight individuals with type 2 diabetes are able to achieve and maintain 7 percent to 10 percent or greater weight loss over the course of one year," researcher Mark Espeland, PhD, tells WebMD.
Espeland works in the public health sciences division of Wake Forest University's medical school.
Weight Loss and Type 2 Diabetes
In type 2 diabetes, the body doesn't respond properly to insulin, a hormone that controls blood sugar. Being overweight or obese makes people more likely to develop type 2 diabetes.
Look AHEAD participants first weighed in, got checkups, and took exercise
tests. Then they were randomly split into two similar groups.
Participants in one group got an intensive lifestyle makeover to help them
lose at least 7 percent of their body weight in the study's first year. They attended dozens of group meetings, ate portion-controlled diets, and got help from behavioral psychologists and exercise specialists.
Their portion-controlled diets included liquid meal replacements or
structured meal plans. Those participants were encouraged to walk or get other physical activity at home.
For comparison, participants in the other group got standard care,
education, and support for their type 2 diabetes, with few group meetings and no specific diet or exercise plan.
Weight Loss Diabetes Results
In a year, participants in the intensive lifestyle program lost 8.6 percent of
their body weight, boosted their aerobic fitness by 21 percent, improved their blood sugar control, and cut back on their need for diabetes and blood pressure medications.
Those in the comparison group lost less than 1 percent of their body weight. But
they did upgrade their fitness somewhat, though not as much as those in the
"Many markers of health improved in both groups," Espeland tells WebMD.
Look AHEAD will continue to see if the short-term results hold up over time. "This is the primary reason for Look AHEAD," says Espeland.
Many Ways to Lose Weight
In the journal, the researchers note that the Slim-Fast Foods Company and
other firms — as well as many government and educational grants — support
But liquid meal replacements weren't necessarily essential to the results.
"While we felt that liquid meal replacements were helpful for many
individuals to achieve and maintain weight loss, we viewed them as one of
several strategies that could be jointly used," Espeland tells WebMD.
"Our protocol was designed to enable individuals to meet study goals for
weight loss using a toolbox of approaches that were tailored to the individual's success. We cannot attribute our overall success to any single approach," says Espeland.
By Miranda Hitti
Reviewed by Louise Chang
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