The comedian filed a Superior Court divorce petition on Monday, saying irreconcilable differences was the reason for the split.
"Drew is a wonderful woman. I love her very much. I wish our marriage could have worked out. I wish her much happiness," Green said in a statement released by his publicist, Ann Gurrola.
Barrymore publicist Jennifer Allen said she was unaware of the divorce filing and she was unable to reach the actress.
Green, 30, and Barrymore, 26, joked for months about whether they were married before tying the knot in July. At one point, they had promised to wed on television's "Saturday Night Live."
In April, Green went on "The Tonight Show" and told Jay Leno that he and Barrymore were expecting a child, but later admitted he was playing a prank that he thought the audience was in on.
The marriage was the first for Green, who starred in and directed the movie "Freddy Got Fingered" this year. It was the second for Barrymore, who most recently starred in "Riding in Cars With Boys."
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