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Michelle Obama, Beyoncé part of Global Citizen Festival all-star lineup

Beyonce performs during 2015 Global Citizen Festival to end extreme poverty by 2030 in Central Park on Sept. 26, 2015, in New York.

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NEW YORK -- First lady Michelle Obama introduced a new campaign focusing on education for girls, Nobel Peace Prize winner Malala Yousafzai earned loud applause for her striking speech and Beyonce was energetic during her live performance at the 2015 Global Citizen Festival.

The multihour event held on the Great Lawn in New York's Central Park also featured Vice President Joe Biden, Hugh Jackman, Bono, Leonardo DiCaprio and Pearl Jam, who closed the event with a rocking performance.

Obama first appeared in a video promoting the 62 Million Girls campaign, but she later walked onstage after Beyoncé introduced her following her performance.

"Let's give it up for the amazing Beyoncé," Obama said. "I am thrilled to be here tonight ... and honored to follow a woman who I admire and adore."

Obama said she has traveled the world and met with young women who have not had a chance to receive an education. She asked the audience to tweet photos of themselves with the hashtag #62MillionGirls and say what you learned in school. Obama said she learned how to "speak up" in school.

"Right now 62 million girls are not in school... they deserve the same chances to get an education as my daughters and your daughters," she told the feverish audience, who cheered her on.

President Barack Obama also appeared in a video at the event, in its fourth year and aimed at ending poverty around the world. The festival is timed to coincide with the U.N. General Assembly meeting, and fans earned free tickets by taking actions to end poverty on globalcitizen.org.

Yousafzai, the 18-year-old Pakistani activist, was passionate as she spoke about fighting for the right for all children to receive an education.

"I want education to be the top priority because how can we end poverty... when we deny the right to education," she said. "It's not that there is lack of money in this world... we have billions and trillions of dollars, but where the money goes is military, it's things that are useless and that are not useful to society."

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Activist Malala Yousafzai, center, speaks on stage at the 2015 Global Citizen Festival in Central Park on September 26, 2015 in New York City.
Theo Wargo/Getty Images

"It is a book and a pen that can change the life of a child -- it's not a gun," Yousafzai added. "It was a gun that hit me on the left side of my forehead, it was a gun that hit my two friends, but it wasn't a pen. But it was a pen (that) really helped us go forward in our lives."

The event, which aired on MSNBC, was hosted by Stephen Colbert, Kerry Washington, Salma Hayek Pinault, Olivia Wilde and other top celebrities. Usher, Jason Sudeikis, Laverne Cox, Katie Holmes, Facebook CEO Mark Zuckerberg and Bill and Melinda Gates also attended the event, along with multiple world leaders, including U.N. Secretary-General Ban Ki-moon.

Backstage was just as star-studded: Everyone from Daniel Craig to Jay Z -- holding daughter Blue Ivy -- was there.

The event featured a number of unique musical collaborations: Beyoncé joined Eddie Vedder onstage; Sting performed with rapper Common; and Ariana Grande sang with Coldplay.

"We could just appear as Coldplay, the English band, or we could take a moment in our set where we cross generations with someone much more talented and much more good looking and by association make us look better," Coldplay lead singer Chris Martin joked. "With that in mind, I talked to my kids and asked who would be the most awesomest person to come sing with us and with deliberation, the amazing young singer Ariana Grande came."

Sheeran even joined Beyoncé for a guitar-based version of her thumping R&B hit "Drunk In Love," which earned roaring applause.

Beyoncé, who changed three times during her set, performed hits from "Crazy In Love" to "Halo" to "Single Ladies."

"I want y'all to feel the connection right now... I want y'all to get lost and dance like children," she told the crowd, adding, "I feel so honored to be on the stage. So many brilliant, generous people out there. All my Global Citizens."