Hallowed Dreams finished the 6-furlong race on a dry Louisiana Downs track in 1:09 2-5, winning by three lengths.
The 3-year-old filly, bought for $15,000 as a 4-month-old, is 16-for-16 and joins Cigar and Citation as the only horses to win 16 straight.
"We just let her break and she takes over," jockey Sylvester Carmouche said.
Hallowed Dreams won $24,000 to boost her career earnings to $390,429, all on Louisiana tracks.
"She's not for sale," co-owner and trainer Lloyd Romero said. "She will remain in Louisiana because she belongs to the people of Louisiana."
Hallowed Dreams paid $2.20 and $2.10, while second-place horse Maddie's Promise, ridden by Anthony Lovato, paid $2.10. Sparkles of Luck finished third in the four-horse race.
The original field was five, but Tuner River was a late scratch.
"This is the greatest thrill of my racing career," said co-owner Johnny Gaspard. "The only filly that can beat this filly is herself."
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