BOSTON -- Former New England Patriots playersuffered substantial damage to parts of the brain that affect memory, judgment and behavior from the most severe case of a degenerative disease linked to head blows ever found in someone so young, a researcher said Thursday.
Dr. Ann McKee, director of Boston University's CTE Center, stressed she could not "connect the dots" between the brain disease chronic traumatic encephalopathy and the behavior of the 27-year-old who hanged himself in April while serving life in prison for murder.
But McKee said CTE had significantly impacted key parts of Hernandez's brain, including the hippocampus -- which is associated with memory -- and the frontal lobe, which is involved in impulse control, judgment and behavior.
"We can say collectively, in our collective experience, that individuals with CTE -- and CTE of this severity -- have difficulty with impulse control, decision-making, inhibition of impulses or aggression, often emotional volatility and rage behaviors," said McKee, who has studied hundreds of brains from football players, college athletes and even younger players, donated after their deaths.
Hernandez hanged himself in prison days after he was acquitted in the 2012 drive-by shootings of two men in Boston and just hours before his former teammates visited the White House to celebrate their latest Super Bowl victory.
Prosecutors contended he gunned the two men down after one accidentally spilled a drink on him in a nightclub - and then got a tattoo of a handgun and the words "God Forgives" to commemorate the crime.
He had been serving a life sentence without parole in the 2013 killing of semi-professional football player Odin Lloyd when he killed himself.
Hernandez, who said he was innocent, did not raise CTE in his defense at either trial.
CTE, which can only be diagnosed in an autopsy, has been found in former members of the military, football players and boxers and others who suffered repeated head trauma.
BU researchers confirmed in September that Hernandez was diagnosed with Stage 3, out of 4, of the disease. But McKee had not publicly discussed her findings until a conference at the university on Thursday.
After Hernandez's CTE diagnosis, his attorneys filed a lawsuit against the NFL and football helmet maker Riddell, accusing them of failing to warn Hernandez about the dangers of football. The lawsuit, which seeks damages for Hernandez's young daughter, said he experienced a "chaotic and horrendous existence" because of his disease.
While the outside of Hernandez's brain appeared normal, the inside was riddled with CTE, said McKee, who showed images of Hernandez's brain next to those of a typical 27-year-old.
In Hernandez's brain, there was evidence of previous small hemorrhages, which is associated with head impacts, she said. Other parts, like the hippocampus, had begun to shrink and large holes were found in his brain's membrane, McKee said.
Before Hernandez, the youngest brain they've examined that showed such severe CTE damage was 46 years old, McKee said.
"These are very unusual findings to see in an individual of this age," McKee said. "We've never seen this in our 468 brains, except in individuals some 20 years older," she said.
Hernandez inherited a genetic profile that may have made him more susceptible to the disease, McKee said.