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Too Few Get Best Migraine Drugs

Too many patients get potentially addictive, under-effective
drugs for migraine -- and too few get the most effective migraine drugs, a new
survey shows.

The Harris Interactive online survey, commissioned by the National Headache
Foundation, polled 502 adult migraine patients in the U.S. The survey also
polled 201 U.S. doctors who treat migraine headaches, including 101
neurologists and 100 primary care doctors.

Surprisingly, the survey shows that one in five migraine sufferers are
taking potentially addictive opioid or barbiturate medications when they get
headaches. Just more than half of migraine patients take the newer, preferred
class of triptan drugs for their headaches.

"I was surprised that triptans are not being used more than they are,
and that so many doctors are prescribing barbiturates and opiates," Brian
M. Grosberg, MD, director of the inpatient headache program at Montefiore
Headache Center, Bronx, N.Y., tells WebMD.

The survey shows that too many doctors have as much to learn as their
patients when it comes to migraine treatment, says Donald B. Penzien, PhD,
director of the head pain center at the University of Mississippi Medical

"Clinical guidelines could not be more clear: Triptans are the
first-line treatment for migraine," Penzien tells WebMD. "If doctors
were doing a better job of getting and giving education, more patients would be
starting with these drugs."

The new survey showed:

  • 60% of triptan users, but only 42% of opioid/barbiturate users, say their
    medicine relieves their migraines "extremely well" or "very

  • 80% of doctors say they are at least somewhat satisfied with the
    side-effect profiles of triptans. But only 17% of doctors say this about
    opioids, and only 12% say this about barbiturates.

  • Patients taking opioids and barbiturates for migraine are more likely than
    those who take triptans to report that migraines "always" limit their
    daily activities.

  • An astonishing 36% of migraine patients who take opioids or barbiturates
    don't know that these drugs are potentially addictive.

Migraine Treatment -- Addictive Drugs Sometimes Needed

Triptan drugs include Amerge, Axert, Frova, Imitrex, Maxalt, Relpax, and
Zomig. They are specifically approved by the FDA for the treatment of

Neither opioids nor barbiturates are FDA-approved treatments for migraine.
Opioids include morphine, codeine, and related medications. Drugs that contain
opioids include OxyContin, Darvon, and Vicodin. The barbiturates family of
drugs includes butalbital (Fiorinal, Fioricet), which has often been prescribed
for migraine patients.

Few doctors still prescribe opioids or barbiturates as first-line migraine
treatments. But when a first treatment fails, the survey shows that 25% of
general practitioners -- but only 7% of neurologists -- prescribe the drugs as
second-line treatments.

This doesn't mean that these potentially addictive drugs should never be
used. Triptans don't work for everyone -- and people at risk of heart disease
or stroke can't take them.

"There may be patients using opiate medications to manage their
headaches in a very appropriate way," Penzien says. "It should not be a
first-line choice -- but the truth is, there is a substantial minority of
patients for whom triptans have no effect or have too many side effects.
Triptans are a godsend to many patients, but they are not the entire answer to
migraine treatment."

The role of barbiturates is much more controversial -- despite doctors'
decades-long history of prescribing butalbital for severe headaches.

"Butalbital has been used forever without any clinical trial evidence
that it is effective," Penzien says. "The potential for dependence and
withdrawal is clearly there. Barbiturates should be used only in a limited
fashion, and in clearly controlled circumstances."
Grosberg agrees that while barbiturates are a controversial migraine
treatment, they may be helpful for patients whose individual circumstances
preclude other treatments.

"It's never good to use a cookie-cutter approach. Each patient has
different needs, so treatment must be tailored to the patient," he says.
"If people are having very frequent headaches, they should certainly not be
prescribed opiate or barbiturate medications -- but it is important to not
overuse any type of headache medicine."

Overtreatment: A Common Cause of Migraine

The average patient in the survey reported five migraine headaches a month.
That puts them at risk of what doctors call "rebound headache" --
headaches caused by too-frequent doses of headache medicine.

"Patients really must limit acute-headache medications to no more than
two days a week -- obviously except for the occasional very bad week -- to
avoid rebound headache," Grosberg says.

"About 15% of our patients come in with medication-overuse headache,
usually from overtreatment with opioids or barbiturates," Penzien says.
"Our first job is to get patients to stop using medicines prescribed by
well-meaning doctors. And for many, that is all they need. We get them over
rebound headaches, and that is all they need for control."

That's because well-managed migraines become less and less of a problem.

"When you have confidence in your own ability to manage headache
symptoms, they don't distress you as much," Penzien says. "Distress is
one of the triggers for migraine. If you sense a migraine coming on and you
think, 'Oh, I am going to spend the rest of the day writhing in bed,' it is
distressing and your headache is worse. When you have a treatment you know will
help, you feel more in control, and you avoid that trigger."

Penzien and Grosberg note that triptans, opiates, and barbiturates aren't
the only treatments for migraine. There's also a role for over-the-counter
painkillers such as ibuprofen and naproxen -- although like their prescription
counterparts, these drugs can have serious side effects and should never be
taken regularly without a doctor's advice.

Nondrug strategies, such as stress management and improved sleep hygiene,
also play a major role in migraine control.

Migraine Prevention

Patients experiencing as many headaches as the average survey patient may
also benefit from another treatment strategy: prevention.

"With five headaches a month, the average patient in this survey would
be well advised to consider a preventative medication to help manage their
problems with rebound and side effects and reduce their need for acute-headache
medications," Penzien says.

The FDA has approved two drugs for migraine prevention: Topamax, an
anticonvulsant; and Inderal, a blood-pressure-lowering medication. However,
doctors often prescribe any of a number of other medications not specifically
approved for migraine prevention.

"None of the migraine preventives were actually invented for prevention
of migraine, but for other types of conditions," Grosberg notes.
"Prescription drugs used for migraine prevention include beta-blockers,
calcium-channel blockers, tricyclic antidepressants, antiseizure medications,
and even Botox. Nonprescription drugs include magnesium, riboflavin, and a
butterbur-root extract called Petadolex."

Headache treatment isn't simple. Patients who suffer frequent migraines
should consider asking their primary care doctor for a referral to a
neurologist or a headache specialist, Penzien and Grosberg suggest.

Both stress the need for more patient education -- and for a lot more doctor

"The sad truth is that many doctors remain to be educated about the
state of the art of migraine therapy," Penzien says. "Doctors have to
partner with migraine patients and educate them about their disorder and the
management of thadisorder. That is a role doctors aren't handling very

By Daniel DeNoon
Reviewed by Brunilda Nazario
B)2005-2006 WebMD, Inc. All rights reserved

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