Terms of the deal were not announced for the actors who provide the voices for Homer and Marge Simpson and other characters on the long-running animated series.
"We couldn't be happier to have reached a multiyear deal with the enormously talented cast of 'The Simpsons,"' series producer 20th Century Fox Television said Friday in a statement.
A spokesman representing the cast said they had no immediate comment.
Despite speculation the dispute would shorten the 2004-05 season, the studio said it was optimistic that all 22 planned episodes could be finished.
The loss of even a few episodes of "The Simpsons," a bulwark of Fox TV's schedule, would be financially painful for the network.
Each cast member was seeking about $360,000 an episode, or $8 million for the 22-episode, 2004-05 season, the trade paper Daily Variety reported previously. The actors were earning $125,000 an episode.
The contract dispute involves Dan Castellaneta (Homer); Julie Kavner (Marge); Hank Azaria (Moe, Apu and others); Harry Shearer (Mr. Burns and others); Yeardley Smith (Lisa) and Nancy Cartwright (Bart), the paper said.
The actors' previous deal, which covered seasons 13, 14 and 15, was reached without complication.
In 1998, however, the cast - except for Kavner, who had a previous deal in effect - sought significant pay increases. At that time, the performers made $30,000 an episode from a show that has proved a huge international moneymaker.