On "The View" Tuesday, O'Donnell said Ripa reacted with a homophobic comment after Clay Aiken put his hand over her mouth while co-hosting "Live With Regis and Kelly."
During a segment Friday with Emmitt Smith and Cheryl Burke, Ripa told Clay his actions were a "no, no," adding, "I don't know where that hand's been, honey."
"If that was a straight man, if that was a cute man, if that was a guy she didn't question his sexuality, she would have said a different thing," O'Donnell said. "I guarantee if that was Mario Lopez, she would not have said the same thing."
Aiken has been dogged by speculation about his sexuality but he's never answered.
In a call to "The View" today, Ripa blasted O'Donnell's comment as "outrageous." She said Aiken's actions were disrespectful and unprofessional — and that he was spreading germs, since he'd just shaken hands with a lot of audience members.