He will wake up in Riyadh, Saudi Arabia and travel to Cairo in the morning where he will immediately participate in a welcome ceremony at the Quba Palace.
Following the meeting he will hold a bilateral meeting with President Mubarak of Egypt before he and Secretary of State Clinton tour the Sultan Hassan Mosque.
Following his afternoon speech, the president will tour the Pyramids and the Sphinx. Here is more from the White House press office (all times Eastern):
2:10AM: President Obama arrives in Cairo, Egypt
2:20AM: President Obama departs Cairo Airport en route to Quba Palace
2:40AM: President Obama participates in welcome ceremony
3:00AM: President Obama holds bilateral meeting with President Mubarak
4:50 AM: President Obama and Secretary of State Clinton tour Sultan Hassan Mosque
6:10 AM: President Obamagives remarks at Cairo University
8:45 AM: President Obama tours The Pyramids and Sphinx
11:00 AM: President Obama departs Cairo en route to Dresden, Germany