Oprah Pick Topples Harry Potter

Oprah does it again. Thanks to a plug on Winfrey's TV talk show, a health guide has accomplished what Jane Fonda, "The Da Vinci Code" and books by the new pope couldn't - knock Harry Potter off the top of the best seller charts.

"YOU: The Owners Manual," co-written by Dr. Michael Roizen and Dr. Memhet Oz, was No. 1 on both Amazon.com and Barnes & Noble.com as of Wednesday, ending, or at least interrupting, the months long reign of "Harry Potter and the Half-Blood Prince." J.K. Rowling's book, which comes out in July, was No. 2 on the lists of both online retailers.

Among the books that failed to displace Potter were Fonda's revelatory memoir "My Life So Far," Dan Brown's multimillion-selling thriller "The Da Vinci Code," and "Truth and Tolerance," one of many works by the former Cardinal Joseph Ratzinger that sold strongly after he was elected the new pope.

"YOU," published Tuesday by HarperCollins, is described on the cover as "An Insider's Guide to the Body That Will Make You Healthier and Younger." Roizen and Oz appeared in a taped interview Tuesday on Winfrey's show, during which former President
Clinton discussed his recent heart problems.

According to HarperCollins associate publisher Libby Jordan, the print run for "YOU" has been increased from 145,000 to 350,000.

Oz is a professor of surgery and director of the Cardiovascular Institute at Columbia University. Roizen, author of the best-selling "RealAge," is chairman of the Division of Anesthesiology, Critical Care Medicine and Comprehensive Pain Management at the Cleveland Clinic.