In an hour-long ABC "Primetime Live" special set to air Tuesday night (10 p.m. ET), Pitt talks to Diane Sawyer about the humanitarian crisis in Africa.
"I can't get out of the press. These people can't get in the press. So let's redirect the attention a little bit," he tells Sawyer.
"We have the potential to end poverty (in Africa) in our time. ... Man — I mean, what is more exciting than that? The potential's there. We gotta go for it."
Pitt separated from Jennifer Aniston in January after 4 1/2 years of marriage. Aniston, 36, filed for divorce in March, citing irreconcilable differences.
He calls tabloid speculation that his "Mr. and Mrs. Smith" co-star Angelina Jolie played a role in the breakup of his marriage "a good story."
Says Sawyer: "But that's painful too.