CBS affiliate KHOU reports the new cases bring to 34 the number of confirmed cases in the area.
The meningitis outbreak has added to concerns raised late last year about Houston's potential for epidemic as the city with the lowest vaccination rate in the nation. Officials say the city is already vulnerable to disease because of its role as a major port and airline hub.
On Thursday, the CDC declared a meningitis outbreak in Montgomery County, just north of Houston, where 11 cases have been reported.
The two new cases reported during the weekend were in Fort Bend County, in suburban southwest Houston.
One case nvolved an eighth-grade student at Lamar Junior High School who was taken to the emergency room after developing symptoms of the disease.
A 13-year-old boy and a 56-year-old woman in the Houston area have died of the disease in the past two weeks.
More than 8,000 people lined up Saturday outside New Caney Middle School in Porter, 25 miles north of Houston, for vaccinations.
The Texas Department of Health recommended vaccines for students from that school district, where three cases had been confirmed. The state is vaccinating only those aged 2 to 24.
Residents in the New Caney district can still receive vaccine at local clinics Monday, officials said.
The Montgomery County Health Department in Conroe will also be administering the vaccine.
Another immunization program is set this week for the 3,600 students in the Humble school district in northeast Harris County, where five cases have been reported.
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