Karen George, of Manhattan, lives above Madonna in a building next to Central Park.
She says in a lawsuit against Madonna and the building's co-op board that the Material Girl is using her apartment as a rehearsal studio, forcing neighbors to endure "blaring music, stomping and shaking walls" for up to three hours each day.
George complained about "unreasonably high-decibel, amplified music" and vibrations pouring through walls, ceilings and radiators.
The building's board says it has already threatened to evict Madonna.
It's all led one New York tabloid to label Madonna the "neighbor from hell."
Madonna's representatives didn't immediately respond to a request for comment.
But attorney Steven Wagner told CBS News, "In the city, people live on top of each other all the time. And there is a degree that is tolerated and must be tolerated. ... Because of the difficulty of proving these types of cases ... I'd put my money on Madonna."
There is, observes CBS News Correspondent Terrell Brown, a lot at stake. A local real estate appraiser told CBS Newsapartments have sold for between $1 million and $5 million in the building within the past year and, if noise complaints turn out to be valid, they could affect the value of nearby apartments by several hundred thousand dollars.