"Everybody in the cast worries about being killed off, and we wouldn't know until they handed us the script — three days before shooting," the 37-year-old actor says in the November issue of Men's Journal magazine.
"It's a sensitive issue. People have houses here, kids in school. Most of us aren't in our twenties anymore."
Holloway's Sawyer has developed into both a villain and a fan favorite.
"It still shocks me how people love him," he says. "But my take on guys like him is they're just dudes who have a different perspective on how to survive. Truth is, there's a little Sawyer in all of us, and that's why people get into him."
Holloway will play another bad boy — a kidnapper — in the thriller "The Whisper," slated for release next year.
"It's a fun movie," he said, "but I'm looking to do a really different role next, more of a character who maybe even keeps his shirt on most of the time."