The telethon, broadcast live from Las Vegas, raked in nearly $64 million, topping last year's event by $3 million. This was Lewis' 42nd telethon.
Lewis has conquered both age and illness to anchor every telethon for more than half of his 81 years. He showed no signs of slowing as he asked for pledges.
While he spent many of the final hours of the 21 1/2 hour show behind a desk, his forays on stage to greet guests were spry and witty. Lewis vowed to "be here every year as long as I'm breathing in and out."
The telecast has raised $1.46 billion to fight the disease since it began in 1966 on a single television station in New York City.