Winning the dramatic-acting honors were Sandra Bullock for the football tale "The Blind Side"and Jeff Bridges for the country-music story "Crazy Heart."
Bullock sat down with "Early Show" weather anchor and features reporter Dave Price after her win.
Price said Bullock's career has gone on "hyperspeed," pointing out that she almost didn't take on "The Blind Side" role.
Bullock responded, "It's crazy, isn't it? I almost didn't do a lot of things that I'm so happy someone forced me to do or talked me into because I think I don't know what's best for me."
Price said, "You are the hottest in so many ways. You're the hottest actress in Hollywood right now."
"That's malarkey," she said, holding her Golden Globe award. "Everything is momentary. Everything is just right now. Tomorrow everything will change and people will want to kick me off my high horse, and all the backlash. We know it's coming."
Bridges said his win was of the comic book kind.
"Wow. Zowie," he said of the night's announcement.
The acting prizes for musical and comedy went to Meryl Streep for the Julia Child story "Julie & Julia" and Robert Downey Jr. for the crime romp "Sherlock Holmes." The supporting-performance Globes were won by Mo'Nique as an abusive welfare mother in "Precious" and Christoph Waltz as a gleefully bloodthirsty Nazi in "Inglourious Basterds."
Mike Tyson, one of the winners of the top prize for best comedy/musical "The Hangover," told Price he wasn't going to be a chaperone for the evening.
"I need chaperoning. My wife is with me," she said. "I need chaperoning. I have issues."
Photos: Golden Globe Couples
Photos: Movie Stars on the Red Carpet
Photos: TV Stars on the Red Carpet
Photos: Ceremony Highlights
Photos: Focus on Fashion
Photos: Golden Globe Winners
Golden Globes Honor Scorsese
In the TV awards, "Mad Men," an acclaimed series about a 1960s-era ad agency, won its third straight award for best television drama, part of a big night for cable networks. The competitive pay cable networks Showtime and HBO both won three trophies.
"Mad Men" won despite a big night for Showtime's "Dexter." Michael C. Hall won for best actor in a drama and John Lithgow won a supporting actor honor. Both men play serial killers who match wits on the bloody series.
Hall, who is undergoing treatment for Hodgkin's lymphoma, wore a wool cap as he accepted his award. He did not mention his illness.
"`I've had the most wonderful time creeping out the entire country for the last six months," said Lithgow, whose Trinity killer joined the series this season.
The Golden Globe could give a burst of attention to Collette's series, "United States of Tara" at least, that was her expressed hope.
Julianna Margulies won for best actress in a drama for her performance as a lawyer fighting back from the humiliation of her disgraced politician husband in "The Good Wife." It was her first Golden Globe in seven nominations, and she kissed her fellow "ER"' actor George Clooney on the way to the stage.
"`It was enough to be nominated with these wonderful women and Glenn Close, I'd bow down, but this dress would rip,"' said Margulies, the only nominee in her category from a broadcast network. The CBS drama is in its first year.
HBO's "Grey Gardens," about reclusive mother and daughter Edith and "Little Edie" Bouvier Beale, relatives of Jacqueline Kennedy Onassis, was judged the best movie or miniseries made for TV. Drew Barrymore, who co-starred with Jessica Lange, took the prize for best actress in a miniseries or TV movie for her role as the eccentric "Little Edie."
A nervous Barrymore accepted the award, thanking producers for taking a chance on her for the role even though she's known to have a goofy reputation.
"Oh, God, I'm not very good at this," she said, stumbling through her speech.
Later, she told Price, "I'm still shaking. I don't know when the dust will settle. But I'm very glad that I'm a person who doesn't take anything for granted. And it's a moment, and I'm trying to be very present, but I'm absolutely in awe and totally in a parallel universe right now."
Kevin Bacon, who played a Marine escort for the remains of troops killed in Iraq in the HBO move "Taking Chance," won for acting in a made-for-TV movie.
Alec Baldwin, who won the trophy for best actor in a TV series, comedy or musical, for "30 Rock"' was attending a charity function and was not present to pick up the prize at the Beverly Hills Hotel ceremony.
The prize Sunday marks a dramatic turning point for Mo'Nique, who was mainly known for lowbrow comedy but startled audiences with her ferocious performance in "Precious: Based on the Novel 'Push' By Sapphire."
The Globe win could boost Mo'Nique's prospects at the Oscars, whose nominations come out Feb. 2.
"First let me say, thank you, God, for this amazing ride that you're allowing me to go on," the tearful Mo'Nique told the crowd.
She went on with gushing praise for "Precious" director Lee Daniels and newcomer Gabourey Sidibe, a best dramatic actress nominee at the Globes with her first film role, playing Mo'Nique's abused, illiterate daughter.
"Lee Daniels, the world gets a chance to see how brilliant you are. You are a brilliant, fearless, amazing director who would not waver, and thank you for trusting me," Mo'Nique said.
"Precious" also was up for best drama, along with the sci-fi blockbuster "Avatar," the recession tale "Up in the Air" and the war stories "The Hurt Locker" and "Inglourious Basterds."
The Globes got a makeover, featuring Ricky Gervais as master of ceremonies, the first time in 15 years the show had a host.
Gervais opened by mocking Steve Carell, star of the U.S. version of "The Office," based on Gervais' British comedy series. While a stone-faced Carell watched, Gervais yammered on about how fans love Carell and wonder where he gets his ideas from.
Carell then mouthed and pantomimed, "I will break you," to Gervais, an executive producer on the U.S. version of the show.
Gervais joked about the international causes near and dear to Hollywood stars internationally.
"You can be a little Asian child with no possessions and see a picture of Angelina Jolie and you think, 'mommy,'" he said.
Gervais also jokingly marveled that his 2009 comedy "The Invention of Lying" was not nominated. The movie bombed with critics and audiences.
Rain doused the pre-show, and stars in their finery crowded under umbrellas as storms rolled in.