Huffman, 44, won an Emmy for "Desperate Housewives" in 2005. She also garnered two Golden Globe nominations, one for "Housewives" and one for her movie "Transamerica," as well as an Academy Award nomination.
In "Transamerica," Huffman played a man determined to be a woman through a sex change operation. Immersed in her portrayal of the character, Huffman studied for the part by going to conventions of transgendered people as well as took voice lessons. She also learned everything that is involved with undergoing such an operation.
She also starred in "Sports Night," a great show sans a big audience. Over the years, she has had cameo roles on, "Law & Order," and "Frasier."
Also known as "Flicka," by her family, Huffman grew up in Woody Creek, Colo. She was the youngest of eight children, seven girls and a boy.
At age 15, she was barely out of acting camp when she got her first paying job on a TV after-school special.
Her real training came on the stage in New York, where she was captivated by playwright David Mamet. She's still a key member of Mamet's Atlantic Theater Company.
That's also where, 20 years ago, she met the man she would eventually marry, actor William H. Macy. Huffman was a student and Macy was her teacher. They have been married for nine years.
With a love for acting, Huffman and Macy have worked together often on TV, in the movies and on the stage. Huffman and Macy have two girls, Sofia Grace and Georgia Grace.