Today, the twins' Dylan and Cole Sprouse continue to thrive on screens big and small.
The twins' hit Disney Channel sitcom "The Suite Life of Zack & Cody" and their new show "The Suite Life on Deck" have made them a huge phenomenon in any language -- more than 180 translations have been made.
Originally, "The Suite Life of Zack & Cody" was about two mischievous twin brothers who live in a fancy Boston hotel where their mother is the headliner in a nightclub.
About 100 episodes were filmed in three seasons, according to the hardworking Sprouse brothers.
Their new adventure, "The Suite Life on Deck," isn't all that different from the old show.
According to Cole, it's still Zack and Cody, but they are on a ship. This time around however, neither Ashley Tisdale of "High School Musical" fame nor Kim Rhodes will be part of the cast.
The twin superstars, who are home-schooled on set, sometimes wish they could be ordinary high school kids.
"Sometimes. We went to public schools from kindergarten through seventh grade and it was fun. But we also have three hours a day at school so how can we complain?" Dylan told Early Show co-anchor Harry Smith.
"We have to be thankful for what we have. A lot of kids would love to be in our situation and we realize that," Cole said.
Although it's exciting to be famous, Smith inquired if it was really "as cool as it looks."
"It is definitely -- it's a win/lose situation. You gain a lot perks and like Disneyland and stuff like that, those kind of perks, but you also loose a lot of the normal kid stuff, just walking around going to the movies kind of stuff," said Cole.
Unlike their past, their future isn't scripted.
"I'm not sure now. At this point in time, we just want to go to college. We just want to check out what our options are really," Dylan said.
"We haven't really set our mind to anything specific just yet," Cole said.